SYNCHRONIZATION OF NEURONAL-ACTIVITY IN HIPPOCAMPUS BY INDIVIDUAL GABAERGIC INTERNEURONS
SYNCHRONIZATION OF NEURONAL-ACTIVITY IN HIPPOCAMPUS BY INDIVIDUAL GABAERGIC INTERNEURONS
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DOI：
10.1038/378075a0
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发表时间：
1995-11-02
期刊：
影响因子：
64.8
通讯作者：
SOMOGYI, P
中科院分区：
文献类型：
--
作者：
COBB, SR;BUHL, EH;SOMOGYI, P
神经元活性的同步在皮质网络的运行中至关重要（1）。关于持续的同步振荡，已经提出，动作电位的精确时机是一种有吸引力的信息编码的候选机制（2-5）抑制性中间神经元网络，可以在插入皮质，同步40 Hz活性中起作用（6 7）。在这里，我们证明了单个GABA能中间神经元（8）可以有效地在theta频率下（4-7 Hz）的海马锥体细胞中的自发性触发和亚阈值振荡。此夹带的效率是由于GABA（A）受体介导的超极化突触事件的相互作用，其内在振荡机制在锥体细胞中调整为此频率范围。此外，这种GABA能机制足以同步锥体细胞的发射。因此，由于每个GABA能中间神经元的差异（9,10），超过一千个锥体细胞可能共享由单个神经元建立的常见时间参考。
SYNCHRONIZATION Of neuronal activity is fundamental in the operation of cortical networks(1). With respect to an ongoing synchronized oscillation, the precise timing of action potentials is an attractive candidate mechanism for information coding(2-5) Networks of inhibitory interneurons have been proposed to have a role in entraining cortical, synchronized 40-Hz activity(6,7). Here we demonstrate that individual GABAergic interneurons(8) can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at theta frequencies (4-7 Hz). The efficiency of this entrainment is due to interaction of GABA(A)-receptor-mediated hyperpolarizing synaptic events with intrinsic oscillatory mechanisms tuned to this frequency range in pyramidal cells. Moreover, this GABAergic mechanism is sufficient to synchronize the firing of pyramidal cells. Thus, owing to the divergence of each GABAergic interneuron(9,10), more than a thousand pyramidal cells may share a common temporal reference established by an individual interneuron.