Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components
Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components
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DOI：
10.1016/j.phymed.2004.01.015
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发表时间：
2006-01-01
期刊：
影响因子：
7.9
通讯作者：
Kadota, S
中科院分区：
文献类型：
--
作者：
Banskota, AH;Nguyen, NT;Kadota, S
采用链脲佐菌素（STZ）诱导的糖尿病大鼠模型，研究了云南红豆杉木材水提物和甲醇提取物的降血糖作用。H2O提取物在腹腔内给药时以100 mg/kg剂量显著降低空腹血糖水平33.7%。从木材的活性H2O提取物中，得到三种木脂素，即，分离出异紫杉树脂酚（1）、开环异落叶松树脂酚（2）和紫杉树脂酚（3）作为主要组分。这些木脂素进一步测试其在相同实验模型上的降血糖作用。在100 mg/kg（i. p.）的剂量下，异紫杉树脂醇（1）使糖尿病大鼠的空腹血糖水平降低34.5%，而开环异落叶松树脂醇（2）和紫杉树脂醇（3）分别降低33.4%和20.9%。1和2的降血糖作用强于用作阳性对照的甲苯磺丁脲（200 mg/kg）和丁脲（1 mg/kg）的混合物，其使空腹血糖水平降低24.0%。(c)2005年Elsevier GmbH。All rights reserved.
Hypoglycemic effects of the H2O and MeOH extracts of the wood of Taxus yunnanensis were examined in streptozotocin (STZ)-induced diabetic rats. The H2O extract significantly lowered the fasting blood glucose level by 33.7% at a 100 mg/kg dose on intraperitoneal administration. From the active H2O extract of the wood, three lignans, i.e., isotaxiresinol (1), secoisolariciresinol (2) and taxiresinol (3), were isolated as major components. These lignans were further tested for their hypoglycemic effects on the same experimental model. At a dose of 100mg/kg (i.p.), isotaxiresinol (1) reduced the fasting blood glucose level of diabetic rats by 34.5%, while secoisolariciresinol (2) and taxiresinol (3) reduced by 33.4% and 20.9%, respectively. The blood glucose lowering effects of 1 and 2 were stronger than the mixture of tolbutamide (200 mg/kg) and buformin (1 mg/kg) used as a positive control, which lowered fasting blood glucose level by 24.0%. (c) 2005 Elsevier GmbH. All rights reserved.