Genetic addiction: selfish gene's strategy for symbiosis in the genome
Genetic addiction: selfish gene's strategy for symbiosis in the genome
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DOI：
10.1534/genetics.105.042895
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发表时间：
2006-02-01
期刊：
影响因子：
3.3
通讯作者：
Iwasa, Y
中科院分区：
文献类型：
--
作者：
Mochizuki, A;Yahara, K;Iwasa, Y
分离后宿主杀死或遗传成瘾现象的进化和维持是自相矛盾的。在这种现象中，基因复合体一旦在基因组中建立，就会控制消灭它的宿主细胞死亡，而基因复合体的完整形式将在宿主种群的其他成员中存活下来。至于为什么这些遗传元素被保留下来，这是有争议的，因为宿主杀死的致命影响，或者可能是其他一些对宿主有益的特性。通过分析方法和计算机模拟分析了它们的种群动态。遗传成瘾最终证明，在竞争性遗传元件存在的情况下，基因复合体是有利的。然而，这种优势在没有空间结构的群体中是有限的，例如在混合良好的液体培养中。相反，在结构化的栖息地，如固体介质的表面，成瘾基因复合物的频率可以增加，而不管其初始密度。我们证明基因组通过获得成瘾基因而进化，这对基因组如何作为潜在自私基因的社区进化的一般问题具有影响。
The evolution and maintenance of the phenomenon of postsegregational host killing or genetic addiction, are paradoxical. In this phenomenon, a gene complex, once established in a genome, programs death of a host cell that has eliminated it. The intact form of the gene complex would survive in other members of the host population. It is controversial as to why these genetic elements are maintained, due to the lethal effects of host killing, or perhaps some other properties are beneficial to the host. we analyzed their population dynamics by analytical methods and computer simulations. Genetic addiction till-lied out to he advantageous to the gene complex in the presence of a competitor genetic element. The advantage is, however, limited in a population without spatial structure, such as that in a well-mixed liquid culture. In contrast, in a structured habitat, such as the surface of a solid medium, the addiction gene complex can increase in frequency, irrespective of its initial density. Our demonstration that genomes call evolve through acquisition of addiction genes has implications for the general question of how a genome call evolve as a community of potentially selfish genes.