REACTION OF SQUIRREL-MONKEYS TO INTRATRACHEAL INOCULATION WITH INFLUENZA-A NEW JERSEY-76 (SWINE) VIRUS
REACTION OF SQUIRREL-MONKEYS TO INTRATRACHEAL INOCULATION WITH INFLUENZA-A NEW JERSEY-76 (SWINE) VIRUS
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DOI：
10.1128/iai.16.2.476-479.1977
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
HALL, WC
中科院分区：
文献类型：
--
作者：
BERENDT, RF;HALL, WC
为了确定是否可以建立用于实验室研究的模型，将9只松鼠猴[Saimiri sciureus]用107个中等鸡蛋感染剂量的A/新泽西/8/76（Hsw 1 N1）型流感病毒（猪流感病毒）进行肠道内接种。他们的反应是临床上可检测到的疾病，包括发热、白细胞减少、摄食量减少、呼吸频率增加、偶尔咳嗽、呼吸困难、鼻涕和嗜睡。到第10天，恢复期提前。所有猴排出病毒7-8天。开发了用于疫苗和化疗有效性研究的评分程序（疾病评分）。
To determine whether a model could be established for laboratory investigations, 9 squirrel monkeys [Saimiri sciureus] were inoculated intratracheally with 107 median egg-infectious doses of influenza virus type A/New Jersey/8/76 (Hsw1N1) (swine influenza virus). They responded with clinically detectable illness including fever, leukopenia, decreased food consumption, increased respiratory rate, occasional coughing, labored breathing, nasal discharge and lethargy. Convalescence was well advanced by day 10. All monkeys excreted virus for 7-8 days. A scoring procedure (illness score) was developed for use in studies of vaccine and chemotherapeutic efficacy.