ASSOCIATIONS BETWEEN HLA FREQUENCIES AND PATHOGENIC FEATURES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN SEROCONVERTERS FROM THE AMSTERDAM-COHORT-OF-HOMOSEXUAL-MEN
ASSOCIATIONS BETWEEN HLA FREQUENCIES AND PATHOGENIC FEATURES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN SEROCONVERTERS FROM THE AMSTERDAM-COHORT-OF-HOMOSEXUAL-MEN
复制标题
DOI：
10.1093/infdis/169.6.1244
复制
发表时间：
1994-06-01
影响因子：
6.4
通讯作者：
MIEDEMA, F
中科院分区：
文献类型：
--
作者：
KLEIN, MR;KEET, IPM;MIEDEMA, F
HLA-疾病关联对于了解 1 型人类免疫缺陷病毒 (HIV-1) 感染的发病机制可能很重要。因此，对阿姆斯特丹艾滋病队列研究中已知 HIV-1 血清转化日期的 106 名同性恋男性进行了 HLA 血清学分型。观察到 HLA 类型与 HIV-1 感染致病特征之间的几个显着关联：在原发性 HIV-1 感染期间出现发烧和皮疹的受试者显示 HLA-B62 频率增加（相对风险 [RR]，5.8；P = 0.005）。 CD4(+) T 淋巴细胞快速下降的受试者中 HLA-B35 的频率增加（RR，3.2；P =.021）。 Kaplan-Meier 生存分析显示 HLA-B35 与 CD4(+) 细胞减少之间存在显着关联
HLA-disease associations may be important for understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection. Therefore, 106 homosexual men from the Amsterdam Cohort Study on AIDS with a known date of HIV-1 seroconversion were serologically typed for HLA. Several significant associations between HLA type and pathogenic features of HIV-1 infection were observed: Subjects with fever and skin rash during primary HIV-1 infection showed an increased frequency of HLA-B62 (relative risk [RR], 5.8; P =.005). The frequency of HLA-B35 was increased in subjects with a rapid decline in CD4(+) T lymphocytes (RR, 3.2; P =.021). Kaplan-Meier survival analysis revealed a significant association between HLA-B35 and a decrease in CD4(+) cells to