Clinical Features, Epidemiology, and Climatic Impact of Genotype-specific Human Metapneumovirus Infections: Long-term Surveillance of Hospitalized Patients in South Korea
Clinical Features, Epidemiology, and Climatic Impact of Genotype-specific Human Metapneumovirus Infections: Long-term Surveillance of Hospitalized Patients in South Korea
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DOI：
10.1093/cid/ciz697
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发表时间：
2020-06-15
影响因子：
11.8
通讯作者：
Lee, Mi-Kyung
中科院分区：
文献类型：
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作者：
Lim, Yong Kwan;Kweon, Oh Joo;Lee, Mi-Kyung
背景人偏肺病毒（hMPV）通常引起上呼吸道和下呼吸道感染。在这里，我们对2007年至2016年期间在韩国住院的患者中的hMPV感染进行了长期回顾性监测，并调查了与每种病毒亚型/基因型相关的季节动态和临床特征。通过商业分子检测试剂盒检测患者标本中的hMPV和其他呼吸道病毒。回顾hMPV阳性患者的病历，并进行hMPV亚型/基因型分析。我们还收集了气象数据，并分析了与hMPV活动的关系。在23694例标本中，1275例（5.4%）为阳性，其中94.0%的标本可分为A1、A2 a、A2 b、B1和B2 5种亚型。hMPV基因型不同，临床表现也不同，但hMPV亚型与临床转归无相关性。病毒活动在第13-20周（4月和5月）达到高峰，并与特定的气候因素相关，包括温度、相对湿度、昼夜温度变化、风速和日照时间。这项为期10年的大规模研究提供了有关hMPV亚型相关临床特征和有助于病毒传播的气候因素的有价值信息。
Background. Human metapneumovirus (hMPV) commonly causes upper and lower respiratory tract infections. Here, we performed long-term retrospective surveillance of hMPV infection among patients hospitalized in South Korea between 2007 and 2016 and investigated seasonal dynamics and clinical characteristics associated with each virus subtype/genotype.Methods. Patient specimens were tested for hMPV and other respiratory viruses by commercial molecular assays. Medical records of hMPV-positive patients were reviewed, and hMPV subtype/genotype analysis was performed. We also collected meteorological data and analyzed relationships with hMPV activity.Results. Of 23 694 specimens, 1275 (5.4%) were positive; among them, 94.0% were classified into 5 subtypes (A1, A2a, A2b, B1, and B2). Some clinical manifestations differed according to hMPV genotype; however, there was no correlation between hMPV subtype and clinical outcome. Viral activity peaked at 13-20 weeks (April and May) and was associated with climate-specific factors, including temperature, relative humidity, diurnal temperature variation, wind speed, and sunshine duration.Conclusions. This large-scale, 10-year study provides valuable information about the clinical characteristics associated with hMPV subtypes and climate factors contributing to virus transmission.