Iron-chelating therapy for transfusional iron overload.
Iron-chelating therapy for transfusional iron overload.
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DOI：
10.1056/nejmct1004810
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发表时间：
2011-01-13
期刊：
影响因子：
--
通讯作者：
Brittenham GM
中科院分区：
文献类型：
--
作者：
Brittenham GM
一名患有镰状细胞性贫血的16岁男孩接受经颅多普勒超声检查以评估卒中风险。这项检查显示大脑中动脉的血流速度异常升高。血红蛋白水平为7.2 g/dl，网织红细胞计数为12.5%，胎儿血红蛋白水平为8.0%。开始进行红细胞输注的长期治疗以预防中风。血液学家建议预防性铁螯合疗法。
A 16-year-old boy with sickle cell anemia undergoes routine screening with transcranial Doppler ultrasonography to assess the risk of stroke. This examination shows an abnormally elevated blood-flow velocity in the middle cerebral artery. The hemoglobin level is 7.2 g per deciliter, the reticulocyte count is 12.5%, and the fetal hemoglobin level is 8.0%. Long-term treatment with red-cell transfusion is initiated to prevent stroke. A hematologist recommends prophylactic iron-chelating therapy.