Time of flight mass spectrometry
Time of flight mass spectrometry
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飞行时间质谱分析
DOI：
10.1021/bk-1994-0549
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
M. Guilhaus
中科院分区：
文献类型：
--
作者：
M. Guilhaus
飞行时间质谱法（TOF MS）是在20世纪40年代末发展起来的，但直到20世纪90年代，它的普及程度才得到限制。最近TOF技术的改进，包括正交加速、离子反射镜（reflectron）和高速电子技术，显著提高了TOF分辨率。这种改进的分辨率，结合久经考验的坚固的离子源和四极杆质量过滤技术，使Q-TOF GC-MS成为适合气相色谱分离的小分子分析的核心技术。
Time-of-flight mass spectrometry (TOF MS) was developed in the late 1940’s, but until the 1990’s its popularity was limited. Recent improvements in TOF technology, including orthogonal acceleration, ion mirrors (reflectron), and high-speed electronics, have significantly improved TOF resolution. This improved resolution, combined with well proven rugged ion sources and quadrupole mass filter technology makes Q-TOF GC-MS a core technology for the analysis of small molecules that are amenable to separation by gas chromatography.