Cervical thymus in the mouse
Cervical thymus in the mouse
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DOI：
10.4049/jimmunol.176.11.6484
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发表时间：
2006-06-01
影响因子：
4.4
通讯作者：
Farr, Andrew G.
中科院分区：
文献类型：
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作者：
Dooley, James;Erickson, Matthew;Farr, Andrew G.
虽然胸腺异位在人类中早已被确认，但这种胸腺组织的功能活性或潜在的免疫学意义尚不清楚。在这项研究中，我们描述了小鼠胸腺异位，颈部胸腺组织具有与胸腺相同的一般组织，能够支持T细胞分化，并可以将T细胞输出到周围。出乎意料的是，异位胸腺组织的自身抗原表达模式与胸胸腺不同，这提高了这两种胸腺环境可能投射出不同版本的自我的可能性。
Although thymic ectopy has long been recognized in humans, the functional activity or potential immunological significance of this thymic tissue is unknown. In this study, we describe murine thymic ectopy, cervical thymic tissue that possesses the same general organization as the thoracic thymus, that is able to support T cell differentiation, and that can export T cells to the periphery. Unexpectedly, the pattern of autoantigen expression by ectopic thymic tissue differs from that of the thoracic thymus, raising the possibility that these two thymic environments may project different versions of self.