Fear Extinction Retention: Is It What We Think It Is?

Fear Extinction Retention: Is It What We Think It Is?
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DOI:
10.1016/j.biopsych.2019.02.011
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发表时间:
2019-06-15
影响因子:
10.6
通讯作者:
Fullana, Miquel A.
Fullana, Miquel A.
中科院分区:
医学1区
文献类型:
--
作者:
Lonsdorf, Tina B.;Merz, Christian J.;Fullana, Miquel A.

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在过去的20年里,关于人类恐惧消退的研究激增。这不仅产生了重要的见解,而且还带来了一个新的目标:如何随着时间的推移保持灭绝记忆(即,灭绝保留)。我们认为,在人类恐惧灭绝研究中仍然存在重要的概念和程序挑战,阻碍了该领域的发展。我们用消失保留和消失保留指数来举例说明这些挑战。我们系统的文献检索确定了16种不同的消光保留指数的操作方法。这些不同操作方法之间的相关系数以及恐惧/焦虑测量之间的相关系数在四个独立数据集中显示出广泛的变异性,在数据集中也有类似的发现。我们的研究结果表明,该领域迫切需要标准化。我们讨论了这些结果的概念和实证意义,并为未来的工作提供了具体的建议。
There has been an explosion of research on fear extinction in humans in the past 2 decades. This has not only generated major insights, but also brought a new goal into focus: how to maintain extinction memory over time (i.e., extinction retention). We argue that there are still important conceptual and procedural challenges in human fear extinction research that hamper advancement in the field. We use extinction retention and the extinction retention index to exemplarily illustrate these challenges. Our systematic literature search identified 16 different operationalizations of the extinction retention index. Correlation coefficients among these different operationalizations as well as among measures of fear/anxiety show a wide range of variability in four independent datasets, with similar findings across datasets. Our results suggest that there is an urgent need for standardization in the field. We discuss the conceptual and empirical implications of these results and provide specific recommendations for future work.