Regulation of plasma catecholamine responses to stress
Regulation of plasma catecholamine responses to stress
复制标题
血浆儿茶酚胺对应激反应的调节
DOI：
--
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
R. Mccarty
中科院分区：
文献类型：
--
作者：
R. Mccarty
摘要血浆去甲肾上腺素和肾上腺素水平可准确评价交感-肾上腺髓质系统的功能状态。在实验室大鼠中，血浆中的两种儿茶酚胺水平随着应激强度的增加而单调增加。此外，血浆中的儿茶酚胺反应减少动物反复暴露于相同的应激源（习惯化）。相反，当动物反复暴露于强烈的应激（致敏）时，血浆儿茶酚胺反应显著增加。最后，血浆儿茶酚胺反应显着增加时，以前强调动物暴露于一种新的应激源（disabituation）。非关联过程似乎是暴露于慢性间歇性应激的动物交感肾上腺髓质系统的适应性反应的基础。
Abstract Plasma levels of norepinephrine and epinephrine provide an accurate assessment of the functional state of the sympathetic-adrenal medullary system. In laboratory rats, plasma levels of both catecholamines increase monotonically with increases in stressor intensity. In addition, plasma catecholamine responses are reduced in animals exposed repeatedly to the same stressor (habituation). In contrast, plasma catecholamine responses increase significantly when animals are exposed repeatedly to an intense stressor (sensitization). Finally, plasma catecholamine responses are increased markedly when previously stressed animals are exposed to a novel stressor (dishabituation). Nonassociative processes appear to underlie the adaptive responses of the sympathetic-adrenal medullary system in animals exposed to chronic intermittent stress.