Advances in our understanding of thyroid hormone action at the cellular level.
Advances in our understanding of thyroid hormone action at the cellular level.
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DOI：
10.1210/edrv-8-3-288
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发表时间：
1987-08
影响因子：
20.3
通讯作者：
J. H. Oppenheimer;Harold L. Schwartz;Cary N. Mariash;W. Kinlaw;N. Wong;H. Freake
中科院分区：
文献类型：
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作者：
J. H. Oppenheimer;Harold L. Schwartz;Cary N. Mariash;W. Kinlaw;N. Wong;H. Freake
尽管甲状腺激素的临床和生物学重要性已经被认识了大约100年(1-3年)，但直到最近，我们对这些激素的生物学效应的了解主要是描述性的，并基于观察到的伴随这些激素过剩或不足的影响的目录。然而，在过去的15年里，在确定甲状腺激素在核水平上作用的分子基础方面取得了实质性的进展。在60年代中期，塔塔和他的同事(4，5)首次提出细胞核可能是甲状腺激素作用的靶点。这一推断是基于对用T4治疗的甲状腺切除动物的甲状腺激素影响的连续测量。然而，这一途径的重要性和独特性并没有得到充分的认识(6)。对启动甲状腺激素作用的核部位的充分了解依赖于认识到T3是活性激素，T4在很大程度上是甲状腺激素的前体。
Introduction DESPITE the fact that the clinical and biological importance of the thyroid hormones have been recognized for approximately 100 yr (1–3), until recently our understanding of the biological effects of these hormones has been largely descriptive and based on a catalog of effects observed to accompany an excess or deficiency of these hormones. In the past 15 yr, however, there has been substantial progress in defining the molecular basis of thyroid hormone action at the nuclear level. In the mid-60s Tata and colleagues (4, 5) first proposed that the nucleus might be the target for thyroid hormone action. This inference was based on sequential measurements of thyroid hormone effects in thyroidectomized animals treated with T4. Nevertheless, the importance and uniqueness of this pathway were not fully appreciated (6). Full understanding of the nuclear site of initiation of thyroid hormone action was dependent on the recognition that T3 was the active hormone, that T4 largely served as a precursor ...