Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas
Nonrandom chromosomal abnormalities in acute nonlymphocytic leukemia in patients treated for Hodgkin disease and non-Hodgkin lymphomas
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发表时间：
1977-11
影响因子：
3.1
通讯作者：
J. Rowley;H. Golomb;J. Vardiman
中科院分区：
文献类型：
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作者：
J. Rowley;H. Golomb;J. Vardiman
对10例恶性淋巴瘤治疗后急性非淋巴细胞白血病（ANLL）患者进行髓系细胞染色体分析。7例患者患有霍奇金病，3例患有非霍奇金淋巴瘤，低分化淋巴细胞型。6例患者行放化疗；其中2例仅接受放疗，2例仅接受化疗。从淋巴瘤诊断到随后的白血病的中位时间为58个月。4例患者为骨髓增生综合征的母细胞期，4例为急性髓性白血病，1例为急性早幼粒细胞白血病，10例为红细胞白血病。四名接受强化化疗的白血病患者均无反应。每个病人都有异常的核型。7例患者表现为次二倍体细胞系，2例为假二倍体，1例为超二倍体细胞系。除一人外，所有患者的细胞都缺少B染色体；在8中，这可以被识别为5号。9名患者中有5名缺少7号。17号缺失或重排4例，6号或8号缺失或重排3例。许多核型都很奇怪，有标记染色体和微小染色体。这些患者的核型模式显示与原发淋巴瘤的性质、白血病的类型或所使用的治疗方法无关。在ANLL中发现的重新产生的次二倍体细胞系的染色体模式与治疗后的淋巴瘤相似。然而，在ANLL de novo中，不到一半的患者染色体少于46条，不到10%的患者染色体少于45条。在这项研究中，70%的患者染色体少于46条，40%的患者染色体少于45条。因此，关键问题涉及的因素，目前尚不清楚，倾向于发展的次二倍体模态数在淋巴瘤的ANLL。«少
Chromosomal analyses of myeloid cells were performed on ten patients who had acute nonlymphocytic leukemia (ANLL) following treatment for malignant lymphoma. Seven patients had Hodgkin disease and three had non-Hodgkin lymphoma, poorly differentiated lymphocytic type. Six patients were treated with radiotherapy and chemotherapy; two had radiotherapy only, and two chemotherapy only. The median time between diagnosis of lymphoma and subsequent leukemia was 58 mo. Four patients had the blast phase of a myeloproliferative syndrome, four had acute myelogenous leukemia, one had acute promyelocytic leukemia, and the tenth, erythroleukemia. None of four patients whose leukemia was treated with intensive chemotherapy responded. Every patient had an abnormal karyotype. Seven of the patients showed hypodiploid cell lines, two a pseudodiploid, and one a hyperdiploid cell line. Cells from every patient except one were lacking a B chromosome; in eight, this could be identified as a No. 5. Five of nine patients were lacking a No. 7. Loss or rearrangement of No. 17 was found in four and of Nos. 6 or 8 in three patients. Many of the karyotypes were bizarre, with marker chromosomes and minute chromosomes. The karyotypic pattern seen in these patients showed no correlation with the nature of the originalmore » lymphoma, the type of leukemia, or the therapy used. The chromosomal pattern of hypodiploid cell lines found in ANLL that arose de novo was similar to that occurring in treated lymphoma. However, in ANLL de novo, less than half of the patients had fewer than 46 chromosomes, and less than 10% had fewer than 45 chromosomes. In this study, 70% of the patients had fewer than 46 and 40% had fewer than 45 chromosomes. The critical question thus concerns the factors, as yet unknown, that predispose to the development of hypodiploid modal numbers in ANLL in lymphoma.« less