History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada
History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada
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DOI：
10.1016/j.anai.2010.03.003
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发表时间：
2010-05-01
影响因子：
5.9
通讯作者：
Rousseau, Marie-Claude
中科院分区：
文献类型：
--
作者：
El-Zein, Mariam;Parent, Marie-Elise;Rousseau, Marie-Claude
背景：关于过敏性疾病病史与不同癌症类型之间的相关性的流行病学证据一直不一致。目的：在20世纪80年代进行的一项基于人群的病例对照研究中，检查哮喘或湿疹病史是否与加拿大男性的各种癌症相关。方法：从1979年8月至1986年3月，由一组训练有素的采访者进行了基于问卷的访谈。收集的信息包括自我报告的先前诊断为哮喘和湿疹的病史，药物使用情况，以及3300例癌症病例和512名人群对照中的几个协变量。Logistic回归模型被用来估计哮喘或湿疹与20多种癌症类型以及8种最常见的癌症类型(胃、结肠癌、直肠癌、肺癌、前列腺癌、膀胱癌、皮肤癌和淋巴结)之间的调整优势比(OR)和95%可信区间(CI)。结果：考虑到研究参与者之前报告了疾病的医学诊断和用药情况，哮喘史与所有癌症类型的合并(OR，0.72；95%CI，0.5-1.1)以及类似的湿疹病史(OR，0.66；95%可信区间，0.4-1.1)。虽然哮喘和湿疹与大多数个体类型之间的OR值均小于1.0，但仅有2个OR值显著低于1.0：哮喘和胃癌之间(OR，0.27；95%CI，0.1~0.9)和湿疹与肺癌之间(OR，0.34；95%CI，0.2~0.7)。结论：免疫系统高反应性引起的过敏性疾病可能导致更有效地清除异常细胞，从而降低癌症风险。过敏性哮喘免疫。2010；104：378-384。
Background: Epidemiologic evidence regarding the association between a history of allergic diseases and different cancer types has been inconsistent.Objective: To examine whether a history of asthma or eczema is associated with various cancers among Canadian men in a population based case-control study conducted in the 1980s.Methods: Questionnaire-based interviews were performed by a team of trained interviewers from August 1979 to March 1986. Information collected included self-reported history of a prior medical diagnosis of asthma and of eczema, medication use, and several covariates among 3,300 cancer cases and 512 population controls. Logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between asthma or eczema and more than 20 cancer types combined, as well as for each of the 8 most common cancer types (stomach, colon, rectum, lung, prostate, bladder, skin, and lymph nodes).Results: Considering study participants who reported a prior medical diagnosis of the disease and medication use, a history of asthma was negatively associated with all cancer types combined (OR, 0.72; 95% CI, 0.5-1.1) and similarly for a history of eczema (OR, 0.66; 95% CI, 0.4-1.1). Although ORs between asthma and eczema and most individual types were below 1.0, only 2 ORs were significantly below 1.0: that between asthma and stomach cancer (OR, 0.27; 95% CI, 0.1-0.9) and that between eczema and lung cancer (OR, 0.34; 95% CI, 0.2-0.7).Conclusion: Allergic conditions that result from a hyperreactive immune system might lead to a more efficient elimination of abnormal cells, thus lowering cancer risks. Ann Allergy Asthma Immunol. 2010;104:378-384.