Iron deficiency and child development
Iron deficiency and child development
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DOI：
10.1177/15648265070284s409
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发表时间：
2007-12-01
影响因子：
1.9
通讯作者：
Lozoff, Betsy
中科院分区：
文献类型：
--
作者：
Lozoff, Betsy
铁缺乏症在婴幼儿中普遍存在，特别是在发展中国家。动物模型提供了令人信服的证据表明，尽管铁补充，铁缺乏在大脑生长突增改变代谢和神经传递，髓鞘形成，基因和蛋白质谱。在人类中，有令人信服的证据表明，6至24个月大的缺铁性贫血婴儿在短期和长期结果中存在认知、运动、社会情感和神经生理发育不良的风险。与铁治疗对缺铁婴儿的不一致的发育影响相反，最近在发展中国家进行的关于铁补充剂的大型随机试验一致显示铁的益处，特别是对运动发育和社会情感行为的益处。这些结果表明，在发育早期或铁缺乏变得严重或慢性之前，铁可以预防和/或逆转不良反应。新的发现还指出，需要更多地关注产前缺铁对发育的影响。
Iron deficiency is widespread in infants and young children, especially in developing countries. Animal models provide convincing evidence that, despite iron repletion, iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In the human, there is compelling evidence that 6- to 24-month-old infants with iron-deficiency anemia are at risk for poorer cognitive, motor, social-emotional, and neurophysiologic development in the short- and long-term outcome. In contrast to inconsistent developmental effects of iron therapy for iron-deficient infants, recent large, randomized trials of iron supplementation in developing countries uniformly show benefits of iron, especially on motor development and social-emotional behavior. These results indicate that adverse effects can be prevented and/or reversed with iron earlier in development or before iron deficiency becomes severe or chronic. New findings also point to the need for more attention to the developmental effects of prenatal iron deficiency.