Complementation.
Complementation.
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互补。
DOI：
10.1895/wormbook.1.24.1
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发表时间：
2005
期刊：
影响因子：
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通讯作者：
Karen Yook
中科院分区：
文献类型：
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作者：
Karen Yook
许多基因的突变会导致相似的表型。找到许多具有相同表型的突变不会让你知道你在处理多少基因，以及这些基因有多容易发生突变，直到你能将这些突变分配给遗传基因。基因分配的遗传测试被称为互补测试。这项测试的简单性和稳健性使其成为基因分配的基本遗传工具。然而，这项测试偶尔会出现一些意想不到的结果，这是可以解释的。本章回顾了互补检验及其各种结果，强调了相对罕见但却很有趣的例外，如基因内互补和非等位基因非互补。
Mutations in many genes can result in a similar phenotype. Finding a number of mutants with the same phenotype tells you little about how many genes you are dealing with, and how mutable those genes are until you can assign those mutations to genetic loci. The genetic assay for gene assignment is called the complementation test. The simplicity and robustness of this test makes it a fundamental genetic tool for gene assignment. However, there are occasional unexpected outcomes from this test that bear explanation. This chapter reviews the complementation test and its various outcomes, highlighting relatively rare but nonetheless interesting exceptions such as intragenic complementation and non-allelic non-complementation.