Sensitivity and exposure to indoor allergens in adults with differing asthma severity
Sensitivity and exposure to indoor allergens in adults with differing asthma severity
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DOI：
10.1183/09031936.99.13365499
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发表时间：
1999-03-01
影响因子：
24.3
通讯作者：
Ayres, JG
中科院分区：
文献类型：
--
作者：
Tunnicliffe, WS;Fletcher, TJ;Ayres, JG
在哮喘中，目前还不确定暴露于家庭过敏原的程度与哮喘严重程度之间是否存在关联。在不同哮喘严重程度的受试者中检查了对常见室内过敏原的敏感性和暴露模式。通过皮肤点刺试验和粉尘沉降分析，对28例重度哮喘患者和28例年龄和性别匹配的轻度哮喘患者进行Can f1和Fel dl评估所有严重哮喘受试者至少有一次阳性皮肤试验，28名受试者中有20名对所有三种过敏原均呈阳性。在26名轻度哮喘患者中，有14名接受皮肤点刺试验的患者至少对一种过敏原呈阳性，其中1名患者对三种过敏原呈阳性。除卧室Fel d I外，重度哮喘患者在每个部位对每种过敏原致敏和暴露的比例均显著高于轻度哮喘组致敏和暴露的比例。几何平均过敏原浓度，除了卧室Fel d I，在致敏的严重哮喘患者比致敏的轻度哮喘患者，这是显着的Der p 1在卧室和卧室和客厅samples.These结果支持过敏个体的家庭过敏原暴露程度和哮喘严重程度之间的关联。
In asthma, it is uncertain whether there is an association between degrees of exposure to domestic allergens and asthma severity. The pattern of sensitivity and exposure to common indoor allergens was examined in subjects with differing asthma severity.Sensitivity to house dust mite, dog and cat allergen and exposure to Derp 1, Can f1 and Fel dl were assessed by skin prick tests and settled dust analysis in 28 subjects with severe asthma and 28 age- and sex-matched subjects with mild asthma (two declined skin prick test).All severe asthmatic subjects had at least one positive skin test and 20 of the 28 subjects were positive to all three allergens. Fourteen of the 26 subjects with mild asthma who took skin prick tests were positive to at least one, and one of these subjects was positive to the three allergens tested. Except for bedroom Fel d I, the proportion of severe asthmatics both sensitized and exposed to each allergen at each site was significantly greater than the proportion sensitized and exposed in the mild asthma group. The geometric mean allergen concentrations, with the exception of bedroom Fel d I, were greater in sensitized severe asthmatics than the sensitized mild asthmatics, which was significant for Der p 1 in bedroom samples and Can fl in bedroom and Living room samples.These results support an association between the degrees of domestic allergen exposure in sensitized individuals and asthma severity.