Specific Recognition of Proteins by Array‐Bound Hexanucleotides†
Specific Recognition of Proteins by Array‐Bound Hexanucleotides†
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DOI：
10.1002/anie.201003462
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发表时间：
2010-12
期刊：
影响因子：
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通讯作者：
Alessandra Mescalchin;W. Wünsche;G. Sczakiel
中科院分区：
文献类型：
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作者：
Alessandra Mescalchin;W. Wünsche;G. Sczakiel
最大信息密度：完整的六核苷酸序列空间可以固定在芯片上。用这个4096个序列的阵列分析了许多蛋白质的结合，包括荧光标记形式的HIV-2和HIV-1逆转录酶（图中显示了共有基序）。这项新技术有助于寻找药物先导化合物。
Maximum information density: The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV‐2 and HIV‐1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.WILEY-VCH