At the Second Glance: Stability of Neural Responses Toward Visual Sexual Stimuli
At the Second Glance: Stability of Neural Responses Toward Visual Sexual Stimuli
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DOI：
10.1111/jsm.12653
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发表时间：
2014-11-01
影响因子：
3.5
通讯作者：
Stark, Rudolf
中科院分区：
文献类型：
--
作者：
Wehrum-Osinsky, Sina;Klucken, Tim;Stark, Rudolf
对性刺激的神经反应的研究可以为进一步了解性功能障碍提供重要的基础。尽管我们对性刺激处理的神经关联的认识在过去十年中有了很大的提高，但在神经性反应研究中观察到的效应的稳定性却相当被忽视。目的目前的研究旨在测试男性和女性在1至1.5年的时间内对视觉性刺激的行为和神经反应的稳定性。为了区分性刺激加工的效价和觉醒相关方面，我们不仅使用了性刺激和中性刺激，还使用了积极情绪刺激和消极情绪刺激。方法对56例受试者（女性24例）进行2次评估，评估间隔1 ~ 1.5年。在功能性磁共振成像（fMRI）期间，参与者被动地观看了性、中性、积极和消极的情绪图片。照片被分成24块，每块5张。每个片段在呈现后立即就效价、性唤起和性唤起进行评分。主要结果测量：通过功能磁共振成像和刺激评分测量血氧水平依赖（BOLD）反应。结果fmri分析揭示了一个分布式网络参与性刺激的处理，该网络的大部分在两个评估点都被一致激活。伏隔核、前扣带、枕叶和顶叶皮层在群体稳定性方面表现出最强劲的结果。前扣带皮层、眶额皮层、顶叶皮层和枕叶皮层的反应表现出个体间的稳定性。性别差异仅限于少数感兴趣的区域。结论神经系统对性刺激反应的稳定性不仅体现在群体层面上，也体现在个体层面上。顶叶和枕叶皮层的激活可能反映了对性刺激的注意相关反应的特征。Wehrum-Osinsky S, Klucken T, Kagerer S, Walter B, Hermann A, Stark R.第二眼：视觉性刺激下神经反应的稳定性。中华性医学杂志2014；11:2720-2737。
IntroductionStudies investigating the neural responses toward sexual stimuli can provide an important basis for further understanding disorders of sexual functioning. Although our knowledge of the neural correlates of sexual stimulus processing has increased considerably in the last decade, the stability of the observed effects in studies on neural sexual responses has been rather neglected.AimsThe current study aimed to test the stability of behavioral and neural responses to visual sexual stimuli in men and women over a time span of 1 to 1.5 years. To disentangle valence and arousal-related aspects of sexual stimulus processing, we employed not only sexual and neutral, but also positive and negative emotional stimuli.MethodsA sample of 56 subjects (24 women) was assessed twice, with an interval of 1 to 1.5 years between assessments. During a functional magnetic resonance imaging (fMRI) session, participants passively viewed sexual, neutral, positive, and negative emotional pictures. Pictures were presented in 24 blocks of five pictures each. Every block was rated immediately after its presentation with respect to valence, arousal, and sexual arousal.Main Outcome MeasuresBlood oxygen level dependent (BOLD) responses measured by fMRI and stimulus ratings.ResultsfMRI analyses revealed a distributed network involved in the processing of sexual stimuli, with large parts of this network being consistently activated at both assessment points. Nucleus accumbens, anterior cingulate, occipital and parietal cortex showed the most robust results with respect to group stability. Responses of anterior cingulate, orbitofrontal, parietal and occipital cortex showed interindividual stability. Gender differences were restricted to a few regions of interest.ConclusionsOur data indicate stability of neural responses toward sexual stimuli not only on the group but also on the individual level. Activation of parietal and occipital cortex might reflect a trait like character of attention related responses toward sexual stimuli. Wehrum-Osinsky S, Klucken T, Kagerer S, Walter B, Hermann A, and Stark R. At the second glance: Stability of neural responses toward visual sexual stimuli. J Sex Med 2014;11:2720-2737.