Age-related Deficiencies in Antigen-Specific CD4 T cell Responses: Lessons from Mouse Models.
Age-related Deficiencies in Antigen-Specific CD4 T cell Responses: Lessons from Mouse Models.
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发表时间：
2011-05
影响因子：
7.4
通讯作者：
L. Haynes;J. Lefebvre
中科院分区：
文献类型：
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作者：
L. Haynes;J. Lefebvre
传染病是老年人发病率和死亡率很高的原因。其中一个主要因素是免疫系统中与年龄相关的下降，这会减少感染和疫苗接种的反应。为了了解免疫系统的特定变化如何影响老年人免疫力的产生，免疫学家开发了衰老小鼠模型，允许对免疫系统成分进行实验操作。这些模型已经表明，幼稚CD4 T细胞功能存在显著的年龄相关变化，这些变化有可能影响无数的免疫应答。在这篇综述中，我们将总结这些研究结果的内在变化的CD4 T细胞功能，并讨论这些变化如何影响免疫。
Infectious diseases contribute to significant morbidity and mortality in elderly populations. One of the major contributing factors to this is age-related declines in the immune system that diminish the response o both infections and vaccinations. In order to understand how specific changes in the immune system influence the generation of immunity in older individuals, immunologists have developed aging mouse models that allow for experimental manipulation of immune system components. These models have shown that there are dramatic age-related changes in naive CD4 T cell function that have the potential to impact a myriad of immune responses. In this review, we will summarize these findings on the intrinsic changes in CD4 T cell function and discuss how these changes influence immunity.