Phosphine-Catalyzed Domino Reactions: A Route to Functionalized Bicyclic Skeletons
Phosphine-Catalyzed Domino Reactions: A Route to Functionalized Bicyclic Skeletons
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膦催化的多米诺反应：功能化双环骨架的途径
DOI：
10.1002/chem.201304003
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发表时间：
2014-03-17
影响因子：
4.3
通讯作者：
Huang, You
中科院分区：
文献类型：
--
作者：
Li, Erqing;Huang, You
发展了一种新的反应策略，包括膦催化的顺序[2+3]和[3+2]环化反应。在这个多米诺骨牌反应中，取代的烯丙烯酸酯被用作新的C-4合成子，在温和的条件下合成了双环环戊烷[b]二氢呋喃衍生物，具有良好的非对映选择性和产率。此外，对该反应的不对称变体进行了初步研究，具有中等的对映选择性。
A novel strategy that involves phosphine-catalyzed sequential [2+3] and [3+2] annulation reactions was developed. In this domino reaction, -substituted allenoates were used as novel C-4 synthons, and the bicyclic cyclopenta[b]dihydrofuran derivatives were produced in good to excellent diastereoselectivities and yields under mild conditions. Furthermore, preliminary studies on an asymmetric variant of this reaction proceeded with moderate enantioselectivity.