Cardiac changes in collegiate athletes following SARS-CoV-2 infection and quarantine: a prospective Case-Control study.
Cardiac changes in collegiate athletes following SARS-CoV-2 infection and quarantine: a prospective Case-Control study.
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DOI：
10.1080/07853890.2023.2269586
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发表时间：
2023
影响因子：
4.4
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中科院分区：
文献类型：
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运动员容易感染急性呼吸道感染，包括SARS-CoV-2，这会影响心血管功能。我们旨在评估COVID-19感染和隔离对男女大学生运动员心功能的影响。我们进行了一项单中心、前瞻性、病例对照研究，并对与非sars - cov -2运动员相匹配的不同组的sars - cov -2阳性恢复期运动员进行了经胸超声心动图检查。数据收集时间为2020年8月1日至2021年5月31日。我们评估了61名sars - cov -2阳性运动员（20±1岁，39%女性）和61名对照组（20±2岁，39%女性）。sars - cov -2阳性运动员在感染诊断后平均40±38天进行超声心动图检查。所有sars - cov -2阳性运动员临床收缩期左心室功能正常（LVEF > 50%）。然而，与对照组相比，sars - cov -2阳性运动员表现出轻度低的LVEF（分别为65±6%对72±8%，p < 0.001），当分别对女性和男性运动员进行评估时，这一差异仍然显著。亚分析显示，只有在感染的平均27天内进行影像学检查时才会出现这些差异，而较长的恢复期（≥27天）则没有差异。与男性对照组相比，sars - cov -2阳性男性运动员表现出更高的左心室舒张末期容积和二尖瓣充盈速度。我们的研究揭示了与对照组相比，大学运动员在SARS-CoV-2感染和隔离后的独特性别特异性心脏变化。尽管LVEF轻度降低（仅在感染后的第一周观察到），但未观察到有临床意义的心脏异常。需要进一步研究以了解LVEF的变化是直接归因于感染还是间接归因于隔离导致的运动限制。
Athletes are susceptible to acute respiratory tract infections, including SARS-CoV-2, which can affect cardiovascular function. We aimed to evaluate the impact of COVID-19 infection and quarantine on cardiac function in male and female collegiate athletes. We conducted a single-center, prospective, case-control study and performed transthoracic echocardiography in a diverse group of convalescent SARS-CoV-2-positive athletes following a 10–14–day quarantine, matched to non-SARS-CoV-2 athletes. Data collection occurred from August 1, 2020, to May 31, 2021. We evaluated 61 SARS-CoV-2-positive athletes (20 ± 1 years, 39% female) and 61 controls (age 20 ± 2 years, 39% female). Echocardiography in SARS-CoV-2-positive athletes was performed on average 40 ± 38 days after infection diagnosis. All SARS-CoV-2-positive athletes had clinically normal systolic left ventricular function (LVEF > 50%). However, SARS-CoV-2-positive athletes exhibited mildly lower LVEF compared to controls (65 ± 6% vs. 72 ± 8%, respectively, p < 0.001), which remained significant when evaluated separately for female and male athletes. Sub-analysis revealed these differences occurred only when imaging occurred within a mean average of 27 days of infection, with a longer recovery period (≥27 days) resulting in no differences. SARS-CoV-2-positive male athletes exhibited higher left ventricular end-diastolic volume and mitral filling velocities compared to male controls. Our study reveals unique sex-specific cardiac changes in collegiate athletes following SARS-CoV-2 infection and quarantine compared to controls. Despite a mild reduction in LVEF, which was only observed in the first weeks following infection, no clinically significant cardiac abnormalities were observed. Further research is required to understand if the changes in LVEF are directly attributed to the infection or indirectly through exercise restrictions resulting from quarantine.
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