Pyroptosis in defense against intracellular bacteria.
Pyroptosis in defense against intracellular bacteria.
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DOI：
10.1016/j.smim.2023.101805
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发表时间：
2023-07
影响因子：
7.8
通讯作者：
Lupeng Li;M. Dickinson;J. Coers;Edward A. Miao
中科院分区：
文献类型：
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作者：
Lupeng Li;M. Dickinson;J. Coers;Edward A. Miao
病原微生物侵入人体，触发宿主免疫反应，抵御感染。作为回应，寄主适应的病原菌采用多种毒力策略来克服寄主防御机制。因此，宿主和病原体之间的相互作用是一个动态过程，它塑造了宿主免疫反应的进化。在针对细胞内细菌的免疫反应中，松下垂是一种细胞死亡的溶解形式，是消除细胞内病原体的复制生态位并通过释放危险信号来调节免疫系统的关键机制。本文重点介绍了下垂在对抗细胞内细菌感染中的作用。我们研究了嗜中性粒细胞和肠上皮细胞中上睑下垂的细胞类型特异性作用。我们讨论了上睑下垂的调节机制，包括自噬和干扰素诱导的GTP酶对其的调节。此外，我们强调，虽然寄主适应的病原体通常可以颠覆下垂，但环境微生物可以有效地消除下垂。
Pathogenic microbes invade the human body and trigger a host immune response to defend against the infection. In response, host-adapted pathogens employ numerous virulence strategies to overcome host defense mechanisms. As a result, the interaction between the host and pathogen is a dynamic process that shapes the evolution of the host's immune response. Among the immune responses against intracellular bacteria, pyroptosis, a lytic form of cell death, is a crucial mechanism that eliminates replicative niches for intracellular pathogens and modulates the immune system by releasing danger signals. This review focuses on the role of pyroptosis in combating intracellular bacterial infection. We examine the cell type specific roles of pyroptosis in neutrophils and intestinal epithelial cells. We discuss the regulatory mechanisms of pyroptosis, including its modulation by autophagy and interferon-inducible GTPases. Furthermore, we highlight that while host-adapted pathogens can often subvert pyroptosis, environmental microbes are effectively eliminated by pyroptosis.