Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression.
Signaling mechanism(s) of reactive oxygen species in Epithelial-Mesenchymal Transition reminiscent of cancer stem cells in tumor progression.
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DOI：
10.2174/157488810790442813
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发表时间：
2010-03
影响因子：
2.7
通讯作者：
Sarkar FH
中科院分区：
文献类型：
--
作者：
Wang Z;Li Y;Sarkar FH
活性氧簇(ROS)被认为是细胞内信号转导途径中的第二信使，参与多种细胞过程，包括炎症、细胞周期进展、细胞凋亡、衰老和癌症。近年来，研究发现ROS与肿瘤转移有关，涉及肿瘤细胞的迁移、侵袭和血管生成等过程。新的证据还表明，上皮-间充质转化(EMT)是肿瘤侵袭和转移的重要一步，与新生和获得性耐药密切相关。鉴于最近的研究进展，我们正在总结ROS在EMT中的作用，方法是将ROS的失控与EMT和肿瘤侵袭性联系起来。人们进一步试图总结几种可用于靶向灭活ROS的化学预防药物的作用，表明许多天然药物可用于逆转EMT，这将成为防止肿瘤进展和/或治疗人类恶性肿瘤的新途径，特别是通过杀死与癌症干细胞具有相似特征的EMT类型细胞。
Reactive oxygen species (ROS) are known to serve as a second messenger in the intracellular signal transduction pathway for a variety of cellular processes, including inflammation, cell cycle progression, apoptosis, aging and cancer. Recently, ROS have been found to be associated with tumor metastasis involving the processes of tumor cell migration, invasion and angiogenesis. Emerging evidence also suggests that Epithelial-Mesenchymal Transition (EMT), a process that is reminiscent of cancer stem cells, is an important step towards tumor invasion and metastasis, and intimately involved in de novo and acquired drug resistance. In the light of recent advances, we are summarizing the role of ROS in EMT by cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of ROS, suggesting that many natural agents could be useful for the reversal of EMT, which would become a novel approach for the prevention of tumor progression and/or the treatment of human malignancies especially by killing EMT-type cells that share similar characteristics with cancer stem cells.
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影响因子：
11.2
作者：
Fan S;Meng Q;Saha T;Sarkar FH;Rosen EM
通讯作者：
Rosen EM
DOI：
10.1016/j.bbrc.2008.12.080
发表时间：
2009-02-06
影响因子：
3.1
作者：
Binker, Marcelo G.;Binker-Cosen, Andres A.;Cosen-Binker, Laura I.
通讯作者：
Cosen-Binker, Laura I.
影响因子：
7.8
作者：
Bao, Bin;Prasad, Ananda S.;Swerdlow, Paul
通讯作者：
Swerdlow, Paul
影响因子：
64.5
作者：
Gupta PB;Onder TT;Jiang G;Tao K;Kuperwasser C;Weinberg RA;Lander ES
通讯作者：
Lander ES
影响因子：
5.7
作者：
Choi, Hyunsung;Chun, Yang-Sook;Park, Jong-Wan
通讯作者：
Park, Jong-Wan