Five-year follow-up of health-related quality of life after primary treatment of localized prostate cancer
Five-year follow-up of health-related quality of life after primary treatment of localized prostate cancer
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DOI：
10.1002/ijc.21043
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发表时间：
2005-08-20
影响因子：
6.4
通讯作者：
de Koning, HJ
中科院分区：
文献类型：
--
作者：
Korfage, IJ;Essink-Bot, ML;de Koning, HJ
虽然早期的检测。由于更多的男性面临着初级治疗的长期后果，关于治疗对长期健康相关生活质量（HRQoL）影响的研究很少。我们随访了314名新诊断的局限性前列腺癌患者，从根治性前列腺切除术（n = 127）或外照射放疗（n = 187;中位随访时间= 52个月）前1个月至术后5年。电子邮件地址。在治疗前1个月和治疗后6、12和52个月发送疾病特异性（UCLA PCI）和通用（SF-36、EQ-5D）HRQoL。使用重复测量建模研究随时间推移的HRQoL。12%的膀胱切除术患者在治疗前报告了定期尿漏，在52个月评估时报告了31%。31%的前列腺切除术患者和40%的放疗患者报告了治疗前勃起功能障碍;在52个月的评估中，这些百分比分别为88%和64%。治疗后1年出现勃起功能障碍可视为永久性。前列腺切除术患者在治疗前后的一般功能都比放疗患者好，放疗患者平均年龄大5.9岁，有更多的合并症。随着时间的推移，直肠癌切除术患者的一般身体功能略有改善，但放疗患者则有所下降。年龄与身体分数之间的关系被发现是非线性的。放疗患者的长期身体衰退部分是由于衰老及其对健康的非线性影响，尽管不能排除治疗效果。两组患者的评分均高于正常人群。描述治疗后疾病特异性和一般功能的创新图表可以帮助患者和医生选择治疗方案。(c)2005 Wiley-Liss，Inc.
Although with earlier detection of. prostate cancer more men face the long-term consequences of primary treatment, studies on the impact of treatment on long-term health-related quality of life (HRQoL) are scarce. We followed 314 men with newly diagnosed localized prostate cancer from 1 month before until 5 years after radical prostatectomy (n = 127) or external beam radiotherapy (n = 187; median follow-up = 52 Months). Questionnaires addressing. disease-specific (UCLA PCI) and generic (SF-36, EQ-5D) HRQoL were sent 1 month before and 6, 12 and 52 months after treatment. Repeated-measures modeling was used to study HRQoL over time. Regular urinary leakage was reported by 12% of prostatectomy patients before treatment and by 31% at the 52-month assessment. Erectile dysfunction before treatment Was reported by 31% of prostatectomy patients and by 40% of radiotherapy patients; at the 52-month assessment, these percentages were 88% and 64%, respectively. Erectile dysfunction present at 1 year posttreatment can be considered permanent. Prostatectomy patients reported better generic functioning both before and after treatment than radiotherapy patients, who were on average 5.9 years older and had more comorbid conditions. General physical functioning of prostatectomy patients slightly improved over time, but declined in radiotherapy patients. The relation between age and physical scores was found to be nonlinear. The long-term physical decline in radiotherapy patients partly resulted from aging and its nonlinear impact on health, although treatment effects cannot be excluded. Scores of both patient groups remained above those of norm populations. Innovative graphs describing disease-specific and generic functions after treatment can help patients and physicians in their treatment choices. (c) 2005 Wiley-Liss, Inc.