Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner
Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner
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DOI：
10.1007/s00256-016-2539-8
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发表时间：
2017-02-01
影响因子：
2.1
通讯作者：
Anderson, Donald D.
中科院分区：
文献类型：
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作者：
Segal, Neil A.;Bergin, John;Anderson, Donald D.
目的 确定使用站立 CT (SCT) 成像进行的膝关节间隙宽度 (JSW) 测量的重测可靠性。 受试者和方法 这项前瞻性两次访问研究包括 30 名受试者的 50 个膝盖（66% 为女性；平均 +/- SD 年龄 58.2 +/- 11.3 岁；BMI 29.1 +/- 5.6 kg/m(2)；38% KL 0-1 级）。胫骨股骨几何形状是从间隔 2 周就诊时采集的双侧约 20 度固定弯曲 SCT 图像获得的。对于每个隔室，总关节面积定义为 JSW < 10 mm 的面积。感兴趣的汇总测量是每个胫股骨隔室中 JSW 小于 0.5 毫米阈值（介于 2.0 和 5.0 毫米之间）的总关节面积的百分比。通过每个 JSW 阈值处参与面积百分比的组内相关系数 (ICC 2,1) 评估 JSW 测量结果的重测可靠性，并计算均方根误差 (RMSE) 以评估再现性。结果 对于每个评估的阈值，ICC 均非常出色，外侧室的 ICC 范围为 0.95 至 0.97，内侧室的范围为 0.90 至 0.97。外侧间室的 RMSE 范围为 1.1% 至 7.2%，内侧间室的 RMSE 范围为 3.1% 至 9.1%，在较小的 JSW 阈值下具有更好的可重复性。 结论 使用的膝关节定位方案显示了间隔 2 周重复的 SCT 3D 胫股 JSW 汇总测量的高日常可靠性。低剂量 SCT 提供了大量有关关节的信息，同时保持高可靠性，使其成为评估膝关节 OA 患者 JSW 的平片的合适替代方案。
Objective To determine the test-retest reliability of knee joint space width (JSW) measurements made using standing CT (SCT) imaging.Subjects and methods This prospective two-visit study included 50 knees from 30 subjects (66% female; mean +/- SD age 58.2 +/- 11.3 years; BMI 29.1 +/- 5.6 kg/m(2); 38% KL grade 0-1). Tibiofemoral geometry was obtained from bilateral, approximately 20 degrees fixed-flexed SCT images acquired at visits 2 weeks apart. For each compartment, the total joint area was defined as the area with a JSW < 10 mm. The summary measurements of interest were the percentage of the total joint area with a JSW less than 0.5-mm thresholds between 2.0 and 5.0 mm in each tibiofemoral compartment. Test-retest reliability of the summary JSW measurements was assessed by intraclass correlation coefficients (ICC 2,1) for the percentage area engaged at each threshold of JSW and root-mean-square errors (RMSE) were calculated to assess reproducibility.Results The ICCs were excellent for each threshold assessed, ranging from 0.95 to 0.97 for the lateral and 0.90 to 0.97 for the medial compartment. RMSE ranged from 1.1 to 7.2% for the lateral and from 3.1 to 9.1% for the medial compartment, with better reproducibility at smaller JSW thresholds.Conclusion The knee joint positioning protocol used demonstrated high day-to-day reliability for SCT 3D tibiofemoral JSW summary measurements repeated 2 weeks apart. Low-dose SCT provides a great deal of information about the joint while maintaining high reliability, making it a suitable alternative to plain radiographs for evaluating JSW in people with knee OA.