The preleukemic syndrome (hemopoietic dysplasia)
The preleukemic syndrome (hemopoietic dysplasia)
复制标题
白血病前期综合征（造血发育不良）
作者：
J. W. Linman;G. Bagby
对急性髓单核细胞（或非淋巴细胞）白血病患者的回顾性分析有助于阐明这种疾病演变的早期阶段，并且已经出现了足够的临床表现，可以进行前瞻性观察。在明显的原始细胞白血病（即，“白血病前期综合征”或“造血发育不良”），并考虑诊断标准和处理方法。这种血液学综合征似乎是多相全脊髓病的一个阶段，涉及骨髓干细胞的所有产物。现有数据表明，这些患者中的大多数在血液学异常发作后24个月内发展为急性白血病，但病程较长的情况并不少见。在准确定义自然病程之前，需要对大量患者进行前瞻性记录;目前正在计划进行此类研究。
Retrospective analysis of patients with acute myelomonoblastic (or non‐lymphocytic) leukemia has helped to clarify the early stages of the evolution of this disease, and a clinical picture has emerged that is sufficiently discriminating to permit prospective observations. The clinical and laboratory features of the hematologic disorder preceding overt, blast‐cell leukemia (i.e., the “preleukemic syndrome” or “hemopoietic dysplasia”) are described, and diagnostic criteria and approaches to management are considered. This hematologic syndrome appears to be a stage in a multiphasic panmyelopathy that involves all products of the marrow stem cell. Available data indicate that most of these patients develop acute leukemia within 24 months of the onset of the hematologic abnormalities, but longer courses are not uncommon. Prospective documentation in a large group of patients is needed before the natural course can be accurately defined; such studies are now being planned.