Effect of fluctuation of oxygenation and time spent in the target range on retinopathy of prematurity in extremely low birth weight infants.
Effect of fluctuation of oxygenation and time spent in the target range on retinopathy of prematurity in extremely low birth weight infants.
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DOI：
10.3233/npm-1757
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Collin, M
中科院分区：
文献类型：
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作者：
Das, A;Mhanna, M;Collin, M
背景：在极低出生体重（ELBW）婴儿中，外周血氧饱和度（SpO2）波动与早产儿视网膜病变（ROP）严重程度之间的关联已得到充分阐明。 SpO2 目标范围内的时间也与 ROP 的严重程度相关。 方法：在一项前瞻性观察研究中，我们科室收治的所有 ELBW 婴儿在生命的前 4 周内均进行 SpO2 监测，并平均每分钟进行分析。计算 SpO2 95% 所花费的时间百分比和每周 SpO2 波动 [作为 SpO2 变异系数 (CoV)]。 结果：在研究期间，21 名婴儿患有中度至重度 ROP，35 名婴儿作为对照。患有中度至重度 ROP 的婴儿比对照组更小、更年轻 [676±124 克 vs. 796±148 克 (p
BACKGROUND: The association between saturation of peripheral oxygenation (SpO2) fluctuation and severity of retinopathy of prematurity (ROP) is well elucidated in extremely low birth weight (ELBW) infants. Time spent in the Target range of SpO2 is also associated with the severity of ROP.METHODS: In a prospective observational study, the SpO2 of all ELBW infants admitted to our unit were monitored for the first four weeks of life, and averaged every minute for analysis. The percent time spent at SpO2 95% and weekly SpO2 fluctuations [as SpO2 coefficient of variation (CoV)] were calculated.RESULTS: During the study period 21 infants had moderate to severe ROP and 35 infants served as controls. Infants with moderate to severe ROP were smaller and younger than their controls [676±124 grams vs. 796±148 grams (p