The role of NOS in heart failure: lessons from murine genetic models.
The role of NOS in heart failure: lessons from murine genetic models.
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DOI：
10.1023/a:1020762401408
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发表时间：
2002-10-01
影响因子：
4.6
通讯作者：
Stewart, Duncan J
中科院分区：
文献类型：
--
作者：
Mungrue, Imran N;Husain, Mansoor;Stewart, Duncan J
一氧化氮合酶 (NOS) 是一组产生一氧化氮 (NO) 的相关蛋白质。在哺乳动物中，该基因家族有 3 个已知成员：nNOS (NOS1)、iNOS (NOS2) 和 eNOS (NOS3)。每一个都被小鼠的靶向基因消融所破坏，并检查了相应的表型。这些小鼠可以在各种实验模型中检查每种 NOS 的贡献，并继续深入了解 NOS 和 NO 的病理生理作用。随着技术的日益成熟，小鼠转基因方法继续为进一步研究 NOS 系统提供丰富的信息和宝贵的工具。本次综述的重点将是对可用工具的检查，以及从心力衰竭背景下的小鼠 NOS 遗传模型研究中获得的见解。
Nitric Oxide Synthases (NOSs) are a group of related proteins that produce nitric oxide (NO). In mammals, there are three known members of this gene family: nNOS (NOS1), iNOS (NOS2) and eNOS (NOS3). Each has been disrupted by targeted gene ablation in mice and the corresponding phenotypes examined. These mice have allowed an examination of the contribution of each NOS in a variety of experimental models and continue to provided insights into the patho-physiological role of NOS and NO. With increasing sophistication, murine transgenic approaches continue to offer a wealth of information, and invaluable tools to further study the NOS system. The focus of this review will be an examination of the tools available, and the insights gained from studies done on murine NOS genetic models in the context of heart failure.