Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey
Chewing suppresses the stress-induced increase in the number of pERK-immunoreactive cells in the periaqueductal grey
复制标题
咀嚼可抑制应激引起的导水管周围灰质 pERK 免疫反应细胞数量的增加
DOI：
10.1016/j.neulet.2015.05.023
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发表时间：
2015
影响因子：
2.5
通讯作者：
Toshiharu Yamamoto
中科院分区：
文献类型：
--
作者：
Kentaro Yamada;Yuri Narimatsu;Yumie Ono;Ken-ichi Sasaguri;Minoru Onozuka;Toshitsugu Kawata;Toshiharu Yamamoto
我们研究了固定应激下咀嚼对中脑导水管周围灰质（PAG）的影响，使用磷酸化的细胞外信号调节激酶（pERK）作为反应细胞的标志物。束缚应激增加PAG中pERK免疫反应阳性细胞。在PAG的四个亚部中，背外侧亚部和腹外侧亚部的免疫反应细胞明显增多。然而，增加pERK免疫反应细胞的制动应力是不那么明显的背内侧和外侧亚部。制动应激下咀嚼可抑制应激引起的背外侧和腹外侧亚区pERK免疫反应阳性细胞的增加，差异有统计学意义（p< 0.05）。同样，咀嚼对pERK免疫反应细胞的影响在背内侧和外侧亚部中不可见。这些结果表明，咀嚼增强了PAG（背外侧和腹外侧分区）对应力的反应。
We investigated the effects of chewing under immobilization stress on the periaqueductal gray (PAG) matter using phosphorylated extracellular signal-regulated kinase (pERK) as a marker of responding cells. Immobilization stress increased pERK-immunoreactive cells in the PAG. Among four subdivisions of the PAG, the increase of immunoreactive cells was remarkable in the dorsolateral and ventrolateral subdivisions. However, increase of pERK-immunoreactive cells by the immobilization stress was not so evident in the dorsomedial and lateral subdivisions. The chewing under immobilization stress prevented the stress-induced increase of pERK-immunoreactive cells in the dorsolateral and ventrolateral subdivisions with statistical significances (p< 0.05). Again, chewing effects on pERK-immunoreactive cells were not visible in the dorsomedial and lateral subdivisions. These results suggest that the chewing alleviates the PAG (dorsolateral and ventrolateral subdivisions) responses to stress.