Effect of HIF1A Gene Polymorphism on Human Muscle Performance
Effect of HIF1A Gene Polymorphism on Human Muscle Performance
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DOI：
10.1007/s10517-008-0291-3
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发表时间：
2008-09-01
影响因子：
0.7
通讯作者：
Rogozkin, V. A.
中科院分区：
文献类型：
--
作者：
Ahmetov, I. I.;Hakimullina, A. M.;Rogozkin, V. A.
研究了低氧诱导因子基因（HIF 1A; Pro582 Ser多态性）在力量型运动员和非运动员中的等位基因分布;研究了速滑运动员基因型与肌纤维组成的关系。通过PCR进行基因分型。肌纤维的组成通过免疫组织化学分析M。股外侧肌举重运动员中HIF 1A Ser等位基因的发生率显著高于对照组（17.9 vs. 8.5%; p=0.001），并随着运动技能的提高而增加。HIF 1A Ser等位基因与快缩肌纤维优势之间存在相关性（Pro/Ser 46.2（13.8）%，Pro/Pro 31.4（8.2）%; p=0.007）。因此，HIF 1A Pro582 Ser多态性与人类肌肉活动相关。
Allele distribution of hypoxia-inducible factor gene (HIF1A; Pro582Ser polymorphism) was studied in power-oriented athletes and controls practicing no athletics; genotype relationships with muscle fiber composition were studied in speed skaters. Genotyping was carried out by PCR. The composition of muscle fibers was evaluated by the immunohistochemical analysis of m. vastus lateralis. The incidence of HIF1A Ser allele was significantly higher in weight-lifters than in controls (17.9 vs. 8.5%; p=0.001) and increased with athletic skill improvement. A relationship between HIF1A Ser allele and predominance of fast-twitch muscle fibers was shown (Pro/Ser 46.2 (13.8)%, Pro/Pro 31.4 (8.2)%; p=0.007). Hence, HIF1A Pro582Ser polymorphism is associated with muscle activity in humans.