Implantable Multi-modality Probe for Subdural Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution
Implantable Multi-modality Probe for Subdural Simultaneous Measurement of Electrophysiology, Hemodynamics, and Temperature Distribution
复制标题
用于硬膜下同时测量电生理学、血流动力学和温度分布的植入式多模态探头
DOI：
10.1109/tbme.2019.2902189
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发表时间：
2019
影响因子：
4.6
通讯作者：
M. Suzuki
中科院分区：
文献类型：
--
作者：
T. Yamakawa;T. Inoue;M. Niwayama;F. Oka;H. Imoto;S. Nomura;M. Suzuki
本文的目的是证明如何将近红外光谱（NIRS）、皮层电图（ECoG）和负温度系数热敏电阻传感器的多通道测量功能集成到一个足够紧凑的用于硬膜下植入的单个设备中，可以提供有关大脑皮层活动各个方面的有益信息，并证明这是一种强大的医疗模式，用于术前、术中、术后和术后。方法研制了一种可同时测量大脑皮层近红外光谱、皮层电图和表面温度的柔性多模态多通道探头。用于NIRS通道的光电裸芯片、用于测量局部温度变化的微型温度系数热敏电阻和用于ECoG记录的3 mm直径铂板组装在聚酰亚胺基柔性印刷电路上，以针对每种模态创建六个通道。Parylene-C的保形涂层被施加在除ECoG之外的所有通道上，以使探针表面具有生物相容性。ResultsAs a first-in-human study，多模态探针的同时测量能力，具有足够的信噪比和准确性，在手术和术后监测期间观察受试者的病理神经活动，自植入两周以来没有并发症，结论确定了使用单个设备从三个不同方面评估人类患者的动态病理活动的可行性。在一个足够小的硬膜下植入装置中的温度记录皮层活动可能在神经外科中具有重要意义，神经科学
ObjectiveThe purpose of this paper is to demonstrate how the integration of the multi-channel measurement capabilities of near-infrared spectroscopy (NIRS), electrocorticography (ECoG), and negative temperature coefficient thermistor sensors into a single device compact enough for subdural implantation can provide beneficial information on various aspects of brain cortical activity and prove a powerful medical modality for pre-, intra-, and post-operative diagnoses in neurosurgery.MethodsThe development of a flexible multi-modal multi-channel probe for the simultaneous measurement of the NIRS, ECoG, and surficial temperature obtained from the cerebral cortex was carried out. Photoelectric bare chips for NIRS channels, miniature temperature-coefficient thermistors for measuring localized temperature variation, and 3-mm-diameter platinum plates for ECoG recording were assembled on a polyimide-based flexible printed circuit to create six channels for each modality. A conformal coating of Parylene-C was applied on all the channels except the ECoG to make the probe surface biocompatible.ResultsAs a first-in-human study, the simultaneous measurement capability of the multi-modality probe, with sufficient signal-to-noise ratio and accuracy, to observe pathological neural activities in subjects during surgery and post-operative monitoring, with no complications two weeks since the implantation, was confirmed.ConclusionThe feasibility of using a single device to assess the dynamic pathological activity from three different aspects was determined for human patients.SignificanceThe simultaneous and accurate multi-channel recording of electrical, hemodynamic, and thermographic cortical activities in a single device small enough for subdural implantation is likely to have major implications in neurosurgery and neuroscience.