Transfer Hydrogenation of Carbonyl Compounds Catalyzed by a Ruthenium−Acetamido Complex: Evidence for a Stepwise Hydrogen Transfer Mechanism
Transfer Hydrogenation of Carbonyl Compounds Catalyzed by a Ruthenium−Acetamido Complex: Evidence for a Stepwise Hydrogen Transfer Mechanism
复制标题
钌-乙酰胺络合物催化羰基化合物的转移氢化：逐步氢转移机制的证据
DOI：
10.1021/om010560m
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发表时间：
2001
期刊：
影响因子：
2.8
通讯作者：
I. Guzei
中科院分区：
文献类型：
--
作者：
Chae S. Yi and;Zhengjie He;I. Guzei
由[(PCy3)2(CO)(CH3CN)2RuH]+BF4-与KOH在异丙醇中反应制得的Ru-−乙酰酰胺络合物是一种有效的羰基化合物和亚胺转移加氢催化剂。观察到了相反的氘同位素效应和添加膦的竞争抑制，为质子和氢化物通过配位不饱和Ru−氨基物种转移的分步机制提供了强有力的证据。
The ruthenium−acetamido complex, prepared from the reaction of [(PCy3)2(CO)(CH3CN)2RuH]+BF4- with KOH in 2-propanol, was found to be an effective catalyst for the transfer hydrogenation of carbonyl compounds and imines. Observation of both the inverse deuterium isotope effect and the competitive inhibition by added phosphine provided strong evidence for a stepwise mechanism of proton and hydride transfer via a coordinatively unsaturated ruthenium−amido species.