Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients
Altered cytokine levels in the blood and cerebrospinal fluid of chronic pain patients
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DOI：
10.1016/j.jneuroim.2008.01.005
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发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
Schell, Kathleen
中科院分区：
文献类型：
--
作者：
Backonja, Miroslav Misha;Coe, Christopher L.;Schell, Kathleen
这项研究重复和扩展了先前关于慢性疼痛患者细胞因子水平异常的报道，并将这些变化与疼痛严重程度相关联。此外，似乎有必要直接评估脑脊液（CSF），因为以前的外周循环中细胞因子浓度的结果不一致。CSF和血液标本来自14例远端疼痛性非糖尿病性多发性神经病（DPPN）或创伤后神经痛（PTN）患者。肿瘤坏死因子（sTNFr）受体水平升高是最显著的异常，沿着白细胞介素-10（IL-10）降低。CSF和血液中的sTNFr以及CSF中的IL-1 β与疼痛强度呈正相关，而两个隔室中的IL-10与疼痛症状呈负相关。促炎细胞因子和抗炎细胞因子的不平衡似乎是临床相关特征，这可能有助于维持慢性疼痛。(C)2008 Elsevier B. V.保留所有权利。
This study replicates and extends prior reports of abnormal cytokine levels in chronic pain patients and has correlated the alterations with pain severity. In addition, there appeared to be a need to directly assess cerebrospinal fluid (CSF) because previous findings on cytokine concentrations in peripheral circulation have been inconsistent. CSF and blood specimens were obtained from 14 patients with distal painful non-diabetic polyneuropathy (DPPN) or post-traumatic neuralgia (PTN). Elevated receptor levels for Tumor Necrosis Factor (sTNFr) were the most distinctive abnormality along with low interleukin-10 (IL-10). sTNFr in CSF and blood, and IL-1 ss in CSF, were positively associated with pain intensity, whereas IL-10 in both compartments was inversely correlated with pain symptoms. An imbalance of pro- and anti-inflammatory cytokines appears to be a clinically relevant feature, which may contribute to the maintenance of chronic pain. (C) 2008 Elsevier B.V. All rights reserved.