Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder
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中枢血清素系统的标记与自闭症谱系障碍的言语能力和副语言社交声音处理相关
DOI：
10.1038/s41598-020-71254-w
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发表时间：
2020
影响因子：
4.6
通讯作者：
Minabe Yoshio
中科院分区：
文献类型：
--
作者：
Yoshimura Yuko;Kikuchi Mitsuru;Saito Daisuke N.;Hirosawa Tetsu;Takahashi Tetsuya;Munesue Toshio;Kosaka Hirotaka;Naito Nobushige;Ouchi Yasuomi;Minabe Yoshio
据报道，自闭症谱系障碍(ASD)患者的言语交流能力受损。5-羟色胺能系统功能障碍在ASD中也有报道。然而，仍不清楚大脑5-羟色胺能系统如何与ASD患者的言语交流能力障碍有关。在本研究中，我们通过脑磁图(MEG)或言语能力测量，研究了脑内5-羟色胺能状态与大脑对副语言刺激(即人类语音韵律变化-诱发失配场的幅度)敏感性的相关性。为了评估大脑5-羟色胺能状态，我们用正电子发射断层扫描[11C]N，N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine([11C]DASB)测量了全脑的5-羟色胺转运体不可移位结合势。结果表明，左侧舌回、左侧梭形回和左侧距骨皮质的5-羟色胺转运体结合电位与大脑对副语言刺激的反应呈显著正相关。此外，右侧前脑岛、右侧壳核和右侧中央盖的语言能力与5-羟色胺能状态呈显著正相关。这些结果表明，枕叶皮质与ASD的韵律变化的识别有关，而右脑岛参与的5-羟色胺能系统在ASD的言语功能培养中起重要作用。试验登记：UMIN000011077。
Impairment in verbal communication abilities has been reported in autism spectrum disorder (ASD). Dysfunction of the serotonergic system has also been reported in ASD. However, it is still unknown how the brain serotonergic system relates to impairment in verbal communication abilities in individuals with ASD. In the present study, we investigated the correlation between brain serotonergic condition and brain sensitivity to paralinguistic stimuli (i.e., amplitude in the human voice prosodic change-evoked mismatch field) measured by magnetoencephalography (MEG) or verbal ability in 10 adults with ASD. To estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11C]N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11C] DASB). The results demonstrated a significant positive correlation between brain activity to paralinguistic stimuli and brain serotonin transporter binding potential in the left lingual gyrus, left fusiform gyrus and left calcarine cortex. In addition, there were significant positive correlations between verbal ability and serotonergic condition in the right anterior insula, right putamen and right central operculum. These results suggested that the occipital cortex is implicated in recognition of the prosodic change in ASD, whereas the right insula-involved serotonergic system is important in nurturing verbal function in ASD.Trial registration: UMIN000011077.