QUANTITATIVE STRUCTURAL-ANALYSIS OF PERIPHERAL AIRWAYS AND ARTERIES IN SUDDEN FATAL ASTHMA
QUANTITATIVE STRUCTURAL-ANALYSIS OF PERIPHERAL AIRWAYS AND ARTERIES IN SUDDEN FATAL ASTHMA
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DOI：
10.1164/ajrccm/143.1.138
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
FABBRI, LM
中科院分区：
文献类型：
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作者：
SAETTA, M;DISTEFANO, A;FABBRI, LM
通过形态计量学方法对六名在哮喘发作期间突然死亡的哮喘受试者尸检肺部的周围气道和邻近的肌性肺动脉进行了研究，并将其与六名死于其他原因且无呼吸道疾病史的对照受试者进行了比较。 哮喘受试者的细支气管管腔闭塞量增加（p < 0.01），平滑肌厚度增加（p < 0.001），炎症浸润增加（p < 0.001），单核细胞和嗜酸性粒细胞均导致炎症增加。 与闭塞和发炎的细支气管相邻的肌性肺动脉不具有慢性缺氧的形态特征，如正常的内侧和内膜厚度所示，但它们的壁上有一个重要的炎症过程，在邻近气道的部位尤其明显。 尽管这些发现的功能意义尚不清楚，但它们可能是急性重症哮喘中观察到的气体交换异常的部分原因。
The peripheral airways and the adjacent muscular pulmonary arteries were studied by morphometric methods in the autopsy lungs of six asthmatic subjects who died suddenly during an asthma attack, and they were compared with those of six control subjects who died of other causes and had no history of respiratory diseases. Bronchioles of asthmatic subjects had an increased amount of lumen occlusion (p < 0.01), smooth muscle thickness (p < 0.001), and inflammatory infiltrate (p < 0.001), and both mononuclear cells and eosinophils contributed to this increased inflammation. The muscular pulmonary arteries adjacent to occluded and inflamed bronchioles did not have the morphologic features of chronic hypoxia, as shown by the normal medial and intimal thickness, but they had an important inflammatory process in their walls that was particularly marked at sites adjacent to airways. Although the functional significance of these findings is unknown, they may be responsible in part for the gas exchange abnormalities observed in acute severe asthma.