Developmental Function in Toddlers With Sickle Cell Anemia
Developmental Function in Toddlers With Sickle Cell Anemia
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DOI：
10.1542/peds.2012-0283
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发表时间：
2013-02-01
期刊：
影响因子：
8
通讯作者：
Wang, Winfred C.
中科院分区：
文献类型：
--
作者：
Armstrong, F. Daniel;Elkin, T. David;Wang, Winfred C.
背景：神经认知障碍发生在儿童和成人镰状细胞性贫血中，但对非常年幼的儿童的神经发育知之甚少。我们检查了参加小儿羟脲III期临床试验（Baby Hug）的婴儿的神经发育状况，以确定其与年龄、脑血流速度和血红蛋白浓度的关系。方法：对193名7至18个月大的血红蛋白SS或血红蛋白s - β(0)地中海贫血的婴儿进行基线评估，对其进行婴儿神经发育的标准化测量。检查神经发育评分与年龄、家庭收入、父母教育程度、血红蛋白浓度和经颅多普勒速度之间的关系。结果：基线神经发育量表的平均功能在平均范围内。没有心理发展分数
BACKGROUND: Neurocognitive impairment occurs in children and adults with sickle cell anemia, but little is known about neurodevelopment in very young children. We examined the neurodevelopmental status of infants participating in the Pediatric Hydroxyurea Phase III Clinical Trial (Baby Hug) to determine relationships with age, cerebral blood flow velocity, and hemoglobin concentration.METHODS: Standardized measures of infant neurodevelopment were administered to 193 infants with hemoglobin SS or hemoglobin S-beta(0) thalassemia between 7 and 18 months of age at the time of their baseline evaluation. Associations between neurodevelopmental scores and age, family income, parent education, hemoglobin concentration, and transcranial Doppler velocity were examined.RESULTS: Mean functioning on the baseline neurodevelopment scales was in the average range. There were no mental development scores