Thyroid hormone and seasonal rhythmicity.
Thyroid hormone and seasonal rhythmicity.
复制标题
DOI：
10.3389/fendo.2014.00019
复制
发表时间：
2014
影响因子：
5.2
通讯作者：
Ebling FJ
中科院分区：
文献类型：
--
作者：
Dardente H;Hazlerigg DG;Ebling FJ
生物在繁殖、增肥、冬眠和迁徙等一系列功能中表现出季节性。在温带地区，光周期的变化维持了年节律与可预测的环境变化的一致性。哺乳动物对光周期变化的适当生理反应需要视网膜检测光和松果体分泌褪黑激素，而鸟类则需要视网膜外检测光。所有脊椎动物的共同机制是这些光周期调节系统改变下丘脑甲状腺激素（TH）的转换。在这里，我们回顾了腺垂体结节部内的昼夜节律钟通过保守的促甲状腺素/脱碘酶轴将光周期解码与中基底下丘脑（MBH）内TH信号的局部变化联系起来的证据。我们还关注了最近的研究结果，这些发现表明，除了光周期控制其转换之外，TH也可能参与季节性节目的长期定时过程。最后，我们研究了kisspeptin和RFRP3这两种在MBH内表达的rf酰胺肽在季节性节律中的潜在意义。
Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment. The appropriate physiological response to changing photoperiod in mammals requires retinal detection of light and pineal secretion of melatonin, but extraretinal detection of light occurs in birds. A common mechanism across all vertebrates is that these photoperiod-regulated systems alter hypothalamic thyroid hormone (TH) conversion. Here, we review the evidence that a circadian clock within the pars tuberalis of the adenohypophysis links photoperiod decoding to local changes of TH signaling within the medio-basal hypothalamus (MBH) through a conserved thyrotropin/deiodinase axis. We also focus on recent findings which indicate that, beyond the photoperiodic control of its conversion, TH might also be involved in longer-term timing processes of seasonal programs. Finally, we examine the potential implication of kisspeptin and RFRP3, two RF-amide peptides expressed within the MBH, in seasonal rhythmicity.
登录
查看更多内容
影响因子：
4.8
作者：
Bentley, George E.;Tucker, Shanna;Perfito, Nicole
通讯作者：
Perfito, Nicole
影响因子：
3.2
作者：
Caraty, A.;Blomenroehr, M.;Beltramo, M.
通讯作者：
Beltramo, M.
影响因子：
7.3
作者：
Coge, F.;Guenin, S. P.;Boutin, J. A.
通讯作者：
Boutin, J. A.
DOI：
10.1016/s0169-328x(03)00134-7
发表时间：
2003-06-10
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Dardente, H;Menet, JS;Masson-Pévet, M
通讯作者：
Masson-Pévet, M
影响因子：
4.1
作者：
Dardente, Hugues;Fortier, Erin E.;Cermakian, Nicolas
通讯作者：
Cermakian, Nicolas