Short report: Lack of sex effect on the pharmacokinetics of primaquine
Short report: Lack of sex effect on the pharmacokinetics of primaquine
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DOI：
10.4269/ajtmh.2006.74.951
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Edstein, MD
中科院分区：
文献类型：
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作者：
Elmes, NJ;Bennett, SM;Edstein, MD
伯氨喹在男性志愿者中的药代动力学已得到很好的定义，但关于该药物在女性中的分布的数据很少。我们比较了伯氨喹的动力学在9名男性和9名女性健康的澳大利亚志愿者后，单次口服剂量（30毫克碱）的伯氨喹。伯氨喹的下列动力学参数在男性和女性之间分别没有观察到统计学差异：（93 +/- 26和115 +/- 38 ng/mL;平均差异的95%置信区间[CI]：-55至10 ng/mL; P = 0.16），曲线下面积（1.1 +/- 0.5和1.2 +/- 0.4 μ g.h/mL; 95% CI：-0.6至0.3 μ g.h/mL; P = 0.54）和清除率（0.34 +/- 0.12和0.39 +/- 0.14 L/h/kg; 95% CI：-0.17至0.08 L/h/kg; P = 0.46）。这些发现的临床意义表明，在为间日疟原虫疟疾的根治或终末预防开出伯氨喹处方时，性别不必作为一个因素加以考虑。
The pharmacokinetics of primaquine have been well defined in male volunteers, but there is little data on the disposition of the drug in women. We compared the kinetics of primaquine in nine male and nine female healthy Australian volunteers after the administration of a single oral dose (30 mg base) of primaquine. No statistical differences were observed in the following kinetic parameters of primaquine between men and women, respectively: maximum plasma concentration (93 +/- 26 and 115 +/- 38 ng/mL; 95% confidence interval [CI] of the mean difference: -55 to 10 ng/mL; P = 0.16), area under the curve (1.1 +/- 0.5 and 1.2 +/- 0.4 mu g.h/mL; 95% CI: -0.6 to 0.3 mu g.h/mL; P = 0.54), and clearance (0.34 +/- 0.12 and 0.39 +/- 0.14 L/h/kg; 95% CI: -0.17 to 0.08 L/h/kg; P = 0.46). The clinical relevance of such findings would suggest that sex does not have to be taken into account as a factor when prescribing primaquine for radical cure or terminal prophylaxis of Plasmodium vivax malaria.