The roles of inflammation and immune mechanisms in Alzheimer's disease.
The roles of inflammation and immune mechanisms in Alzheimer's disease.
复制标题
DOI：
10.1016/j.trci.2016.05.001
复制
发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Bales K
中科院分区：
文献类型：
--
作者：
Van Eldik LJ;Carrillo MC;Cole PE;Feuerbach D;Greenberg BD;Hendrix JA;Kennedy M;Kozauer N;Margolin RA;Molinuevo JL;Mueller R;Ransohoff RM;Wilcock DM;Bain L;Bales K
阿尔茨海默病协会研究圆桌会议于 2015 年 4 月召开，探讨神经炎症机制在阿尔茨海默病 (AD) 进展中的作用。先天免疫细胞（特别是小胶质细胞和星形胶质细胞）介导 AD 中神经炎症的能力被认为是疾病发病机制的重要贡献者。适应性免疫在应对中枢神经系统损伤和某些疾病方面发挥着重要作用，也可能导致 AD 中的神经炎症。中枢和外周免疫系统之间的沟通在 AD 中也可能很重要。加深对先天免疫系统生理学的了解可能有助于识别新的治疗靶点或机制。 AD 预测动物模型和可翻译神经炎症生物标志物的开发也将促进先天免疫新疗法的进步。讨论了阻碍新治疗药物进步的重要挑战以及克服这些挑战的策略。
The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.