Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit
Anti-inflammatory and analgesic activities of ethanolic extract and two limonoids from Melia toosendan fruit
复制标题
DOI：
10.1016/j.jep.2008.02.025
复制
发表时间：
2008-05-22
影响因子：
5.4
通讯作者：
Kou, Jun-Ping
中科院分区：
文献类型：
--
作者：
Xie, Fan;Zhang, Mian;Kou, Jun-Ping
研究目的：川楝子（Melia toosendan Sieb. et Zucc. (MTF)是一种治疗胃痛和多种急慢性炎症以及蛔虫的传统中草药。本文旨在研究MTF提取物和从MTF中分离得到的两种主要的柠檬苦素类三萜类化合物的抗炎镇痛活性。材料与方法：对MTF的乙醇提取物和两种柠檬苦素类化合物isotoosendanin（1）和1-O-tigloyl-1-O-debenzoylohchinal（2）进行抗炎镇痛活性评价。采用醋酸致小鼠血管通透性实验和角叉菜胶致小鼠足跖肿胀实验，醋酸致小鼠扭体实验和热板法观察其抗炎作用。结果：柠檬苦素醇提物和2种柠檬苦素类化合物均具有明显的抗炎作用。结论：MTF乙醇提取物具有明显的抗炎镇痛作用，两种柠檬苦素类化合物是MTF抗炎镇痛的有效成分。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Aim of study: The fruit of Melia toosendan Sieb. et Zucc. (MTF) is a traditional Chinese herbal medicine in the treatment of stomachache and many acute or chronic inflammations, as well as ascariasis. This paper aimed to investigate the anti-inflammatory and analgesic activities of the MTF extract and two main limonoid-type triterpencids isolated from MTF.Materials and methods: The ethanolic extract of MTF and two limonoids, isotoosendanin (1) and 1-O-tigloyl-1-O-debenzoylohchinal (2) were evaluated for their anti-inflammatory and analgesic activities. Acetic acid-induced vascular permeability and lambda-carrageenan-induced hind paw edema tests in mice were used to investigate anti-inflammatory activity; and acetic acid-induced writhing and hot-plate tests in mice were used to determine analgesic effect.Results: Both the ethanolic extract and two limonoids displayed significant anti-inflammatory effects. Although the ethanolic extract showed remarkable analgesic effects in both writhing and hot-plate tests, the two limonoids had analgesic effects just in writhing test.Conclusion: The results suggested that the ethanolic extract of MTF had obvious anti-inflammatory and analgesic activities, and the two limonoids were the active constituents contributing to the anti-inflammatory and analgesic effects of MTF. (C) 2008 Elsevier Ireland Ltd. All rights reserved.