Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries
Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries
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靶向铁死亡：对抗心肌梗死和缺血再灌注损伤的新见解
DOI：
10.1007/s10495-022-01785-2
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发表时间：
2022-12
期刊：
影响因子：
7.2
通讯作者：
Caixia Guo
中科院分区：
文献类型：
--
作者：
Xuejie Han;Jie Zhang;Jian Liu;Hongxia Wang;Fenghe Du;Xiangjun Zeng;Caixia Guo
铁凋亡是一种新发现的依赖于铁和活性氧的调节性细胞死亡形式，其主要特征是线粒体收缩、双层膜密度增加和脂质过氧化积累，引起膜脂质过氧化，最终导致细胞死亡。与大多数形式的调节性细胞死亡类似，铁凋亡也参与心肌梗死和心肌缺血/再灌注损伤的病理代谢，这仍然是全球范围内的主要死亡原因。鉴于铁凋亡在心肌梗死、心肌缺血/再灌注损伤等心血管疾病中的重要作用，深入研究铁凋亡促进心血管疾病进展的分子机制具有重要意义，为铁凋亡作为靶向治疗多种心血管疾病提供了可能。本文系统总结了铁凋亡的发生过程和代谢调控机制，探讨了铁凋亡与心肌梗死及心肌缺血/再灌注损伤的关系，为探讨铁凋亡的病理代谢机制提供了新的思路，并为以铁凋亡为靶点的心肌梗死及心肌缺血/再灌注损伤等心血管疾病的防治提供了新的思路。
Ferroptosis, a newly discovered form of regulated cell death dependent on iron and reactive oxygen species, is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes and the accumulation of lipid peroxidation, causing membrane lipid peroxidation and eventually cell death. Similar with the most forms of regulated cell death, ferroptosis also participated in the pathological metabolism of myocardial infarction and myocardial ischemia/reperfusion injuries, which are still the leading causes of death worldwide. Given the crucial roles ferroptosis played in cardiovascular diseases, such as myocardial infarction and myocardial ischemia/reperfusion injuries, it is considerable to delve into the molecular mechanisms of ferroptosis contributing to the progress of cardiovascular diseases, which might offer the potential role of ferroptosis as a targeted treatment for a wide range of cardiovascular diseases. This review systematically summarizes the process and regulatory metabolisms of ferroptosis, discusses the relationship between ferroptosis and myocardial infarction as well as myocardial ischemia/reperfusion injuries, which might potentially provide novel insights for the pathological metabolism and original ideas for the prevention as well as treatment targeting ferroptosis of cardiovascular diseases such as myocardial infarction and myocardial ischemia/reperfusion injuries.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
14.8
作者：
Kagan VE;Mao G;Qu F;Angeli JP;Doll S;Croix CS;Dar HH;Liu B;Tyurin VA;Ritov VB;Kapralov AA;Amoscato AA;Jiang J;Anthonymuthu T;Mohammadyani D;Yang Q;Proneth B;Klein-Seetharaman J;Watkins S;Bahar I;Greenberger J;Mallampalli RK;Stockwell BR;Tyurina YY;Conrad M;Bayır H
通讯作者：
Bayır H
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
8
作者：
Tadokoro, Tomonori;Ikeda, Masataka;Ide, Tomomi;Deguchi, Hiroko;Ikeda, Soichiro;Okabe, Kosuke;Ishikita, Akihito;Matsushima, Shouji;Koumura, Tomoko;Yamada, Ken-ichi;Imai, Hirotaka;Tsutsui, Hiroyuki
通讯作者：
Tsutsui, Hiroyuki