Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive
Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive
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DOI：
10.1021/ja047755g
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发表时间：
2004-10-13
影响因子：
15
通讯作者：
Kono, K
中科院分区：
文献类型：
--
作者：
Haba, Y;Harada, A;Kono, K
以1，3-二环己基马来酰亚胺为缩合剂，将2 ~ 5代（G）的端氨基聚酰胺-胺树枝状大分子与异丁酸反应，合成了端异丁酰胺（IBAM）树枝状大分子.虽然IBAM封端的G2树枝状聚合物可溶于水，但IBAM封端的G3、G4和G5树枝状聚合物分别在75、61和43 °C下表现出较低的临界溶解温度（LCST）。由于树枝状聚合物周围的末端IBAM基团的密度随着树枝状聚合物代数的增加而逐渐增加，因此IBAM基团的相互作用可能更有效地发生，导致LCST显著降低。此外，IBAM基团连接到聚（丙烯亚胺）树枝状大分子可以给温度敏感的性质，表明这是一个有效的方法，使树枝状大分子的温度敏感。
The poly(amidoamine) dendrimers having terminal isobutyramide (IBAM) groups were prepared by the reaction of isobutyric acid and the amine-terminated poly(amidoamine) dendrimers with generations (G) of 2 to 5 by using a condensing agent, 1,3-dicyclohexylcarbodiimide.1H and13C NMR revealed that an IBAM group was attached to essentially every chain end of the dendrimers. While the IBAM-terminated G2 dendrimer was soluble in water, the IBAM-terminated G3, G4, and G5 dendrimers exhibited the lower critical solution temperatures (LCSTs) at 75, 61, and 43 °C, respectively. Because the density of the terminal IBAM groups in the periphery of the dendrimer progressively increases with increasing dendrimer generation, the interaction of the IBAM groups might take place more efficiently, resulting in a remarkable decrease in the LCST. In addition, attachment of IBAM groups to poly(propylenimine) dendrimers could give the temperature-sensitive property, indicating that this is an efficient method to render dendrimers temperature sensitive.