Cytokine and Chemokine Levels in Patients Infected With the Novel Avian Influenza A (H7N9) Virus in China
Cytokine and Chemokine Levels in Patients Infected With the Novel Avian Influenza A (H7N9) Virus in China
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DOI：
10.1093/infdis/jit440
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发表时间：
2013-12-15
影响因子：
6.4
通讯作者：
Zhou, Minghao
中科院分区：
文献类型：
--
作者：
Chi, Ying;Zhu, Yefei;Zhou, Minghao
H7N9禽流感是一种由甲型H7N9禽流感病毒引起的中国新出现的病毒性疾病。我们通过多重微珠免疫测定法研究了H7N9患者血清样品中宿主细胞因子和趋化因子的谱。统计分析显示，IP-10、IL-6、IL-17和IL-2在H7N9感染患者中升高。此外，IL-6和趋化因子IP-10在严重H7N9患者中显著高于非严重H7N9病例。我们认为，促炎性细胞因子反应，其特征在于组合的Th 1/Th 17细胞因子诱导，是部分负责与H7N9感染患者的疾病进展。
H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Th17 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.