Patient-specific modeling of cardiovascular mechanics.
Patient-specific modeling of cardiovascular mechanics.
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DOI：
10.1146/annurev.bioeng.10.061807.160521
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发表时间：
2009
影响因子：
9.7
通讯作者：
Figueroa CA
中科院分区：
文献类型：
--
作者：
Taylor CA;Figueroa CA
数值方法和三维成像技术的进步使得在特定对象的解剖和生理模型中量化心血管力学成为可能。特定于患者的模型正被用于指导细胞培养和动物实验，并测试与生物力学因素在血管疾病中的作用有关的假说。此外，基于非侵入性医学成像的生物力学模型可以为使用心血管装置的活体服务环境以及装置对生理功能的影响提供宝贵的数据。最后，特定于患者的建模实现了心血管力学的一种全新应用，即预测个别患者的替代治疗干预结果。我们将回顾创建解剖学和生理学模型的方法，获取属性，指定边界条件，并求解控制血流和血管壁动力学的方程。本课程将介绍特定于患者的心血管力学模型的应用，然后讨论未来的挑战和机遇。
Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models. Patient-specific models are being used to guide cell culture and animal experiments and test hypotheses related to the role of biomechanical factors in vascular diseases. Furthermore, biomechanical models based on noninvasive medical imaging could provide invaluable data on the in vivo service environment where cardiovascular devices are employed and the effect of the devices on physiologic function. Finally, the patient-specific modeling has enabled an entirely new application of cardiovascular mechanics, namely predicting outcomes of alternate therapeutic interventions for individual patients. We will review methods to create anatomic and physiologic models, obtain properties, assign boundary conditions, and solve the equations governing blood flow and vessel wall dynamics. Applications of patient-specific models of cardiovascular mechanics will be presented followed by a discussion of the challenges and opportunities that lie ahead.