Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women
Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women
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DOI：
10.1016/j.exger.2018.01.024
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发表时间：
2018-04-01
影响因子：
3.9
通讯作者：
Kim, Do-Yeon
中科院分区：
文献类型：
--
作者：
Kim, Ji-Hyeon;Kim, Do-Yeon
背景：随着老年人口的增加，退行性脑部疾病的患病率增加，这是一个严重的社会问题，定期锻炼可以有效地预防和治疗此类疾病。虹膜蛋白是运动过程中肌肉表达的一种肌动蛋白，与脑源性神经营养因子(BDNF)的表达密切相关。因此，本研究的目的是分析有氧运动对老年女性血清淫羊藿素和脑源性神经营养因子水平的影响，以帮助预防和延缓老年女性退行性脑疾病的发生。材料和方法：26名老年女性自愿参加研究(对照组12名，运动组14名)。运动组接受了为期16周的无氧运动计划。结果：运动16周后，无氧运动组大鼠血清淫羊藿素(p<；0.001)和脑源性神经营养因子(p<；0.05)水平均显著高于对照组，且对照组和运动组均存在明显的交互作用(p<；0.001)。16周第一次运动后30min和最后一次运动后30min的血清淫羊藿素(p<；0.01，p<；0.001)和脑源性神经营养因子(p<；0.001，p<；0.05)水平均显著高于16周前的静息期。结论：有氧运动可提高老年女性血清淫羊藿素和脑源性神经营养因子的水平，从而预防老年女性退行性脑疾病，增强脑功能。
Background: The increase in the prevalence of degenerative brain diseases owing to the growing elderly population is becoming a serious social issue, and regular exercises can be effective in preventing and treating such diseases. Irisin, one of the myokines expressed in the muscles during exercise, is highly associated with the expression of brain-derived neurotrophic factor (BDNF). Therefore, the purpose of this study was to analyze the effect of aquarobic exercises on serum irisin and BDNF levels to help prevent and delay degenerative brain diseases in elderly women.Materials and methods: Twenty-six elderly women voluntarily participated in the study (12 in the control group and 14 in the exercise group). The exercise group underwent a 16-week aquarobic exercise program. The irisin and BDNF levels and liver function were measured in both groups: three times in the exercise group and two times in the control group.Results: Significantly higher serum irisin (p < 0.001) and BDNF (p < 0.05) levels in the aquarobic exercise group than in the control group were found after 16 weeks of exercise, and significant interaction effects of irisin (p < 0.001) and BDNF (p < 0.01) were found in both the control and exercise groups. The serum irisin (p < 0.01 and p < 0.001, respectively) and BDNF (p < 0.05, p < 0.001, respectively) levels were significantly higher 30 min after the first exercise session and 30 min after the last exercise session in the 16th week than during the rest period before the 16 weeks of exercise.Conclusions: Aquarobic exercises were found to improve the serum irisin and BDNF levels; thus, it could be effective in preventing degenerative brain diseases and enhancing brain function of elderly women.