Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis
Immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis
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DOI：
10.1016/j.jneuroim.2006.06.005
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发表时间：
2006-09-01
影响因子：
3.3
通讯作者：
Markovic-Plese, Silva
中科院分区：
文献类型：
--
作者：
Peng, Xueyan;Jin, Jianping;Markovic-Plese, Silva
本研究描述了他汀类药物在人体中的免疫调节靶点及其治疗复发缓解型多发性硬化症（RR MS）的潜力。他汀类药物抑制单核细胞的增殖反应。辛伐他汀，他汀类药物的最强的抗增殖作用，抑制IFN-γ诱导的表达的MHC 11 DR类单核细胞，并降低其抗原呈递能力。对于T淋巴细胞，它抑制其活化和Th 1谱系分化标志物的表达。辛伐他汀抑制IFN-γ、TNF-α和IL-2的分泌，以及调节Th 1细胞分化的转录因子T-bet的表达。(c)2006 Elsevier B. V.保留所有权利。
This study characterized immunomodulatory targets of statins in humans and their potential for treatment of relapsing remitting multiple sclerosis (RR MS). Statins inhibited the proliferative response of mononuclear cells. Simvastatin, the statin with the strongest antiproliferative effect, inhibited IFN-gamma-induced expression of MHC class 11 DR on monocytes and decreased their antigen presenting capacity. As for T lymphocytes, it inhibited their activation and expression of the Th1 lineage differentiation markers. Simvastatin inhibited IFN-gamma, TNF-alpha, and IL-2 secretion, as well as the expression of T-bet, a transcription factor that regulates Th1 cell differentiation. (c) 2006 Elsevier B.V. All rights reserved.