Global burden of influenza as a cause of cardiopulmonary morbidity and mortality.
Global burden of influenza as a cause of cardiopulmonary morbidity and mortality.
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DOI：
10.1016/j.gheart.2014.08.004
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发表时间：
2014-09
期刊：
影响因子：
3.7
通讯作者：
Sevransky, Jonathan
中科院分区：
文献类型：
--
作者：
Fischer, William A 2nd;Gong, Michelle;Bhagwanjee, Satish;Sevransky, Jonathan
包括流感在内的严重急性呼吸道感染（SARI）是全球心肺疾病发病率和死亡率的主要原因。直到最近，流感的流行病学仅限于资源丰富的国家。然而，以2009年H1N1大流行为特征的新流行病学报告表明，流感在低收入资源有限的环境中造成的损失甚至更大，其中5-27%的SARI是由流感造成的。在这种情况下，疾病负担增加是多因素的，可能是合并症（如HIV）发生率较高、获得医疗保健（包括疫苗接种和抗病毒药物）的机会减少以及医疗保健基础设施有限（包括氧气治疗或重症监护支持）的结果。迫切需要改进全球流感流行病学，以指导包括疫苗和抗病毒药物在内的救生资源的分配，并指导改善基本卫生保健，以减轻流感感染对最脆弱人群的影响。
Severe acute respiratory infections (SARI), including influenza, are a leading cause of cardiopulmonary morbidity and mortality worldwide. Until recently the epidemiology of influenza was limited to resource-rich countries. Emerging epidemiological reports characterizing the 2009 H1N1 pandemic however suggest that influenza exerts an even greater toll in low-income resource constrained environments where it is the cause of 5–27% of all SARI. The increased burden of disease in this setting is multifactorial and likely is the results of higher rates of comorbidities such as HIV, decreased access to healthcare including vaccinations and antiviral medications, and limited healthcare infrastructure including oxygen therapy or critical care support. Improved global epidemiology of influenza is desperately needed in order to guide allocation of life saving resources including vaccines, antiviral medications, and direct the improvement of basic health care in order to mitigate the impact of influenza infection on the most vulnerable populations.