Hot and cold cognition in unmedicated depressed subjects with bipolar disorder.
Hot and cold cognition in unmedicated depressed subjects with bipolar disorder.
复制标题
未经药物治疗的双相情感障碍抑郁症患者的冷热认知。
DOI：
10.1111/j.1399-5618.2009.00669.x
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发表时间：
2009
影响因子：
5.4
通讯作者：
Drevets,WayneC
中科院分区：
文献类型：
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作者：
Roiser,JonathanP;Cannon,DaraM;Gandhi,ShilpaK;TaylorTavares,Joana;Erickson,Kristine;Wood,Suzanne;Klaver,JacquelineM;Clark,Luke;ZarateJr,CarlosA;Sahakian,BarbaraJ;Drevets,WayneC
目的：双相情感障碍（BD）患者的神经心理学研究报告了各种认知测量的缺陷。然而，由于大多数受试者在既往研究中检测时接受了药物治疗，目前尚不清楚报告的缺陷模式是否与BD本身或精神药物相关。我们解决了这个问题，通过检查一组未用药的认知性能，目前抑郁症患者BD.Methods：四十九个未用药的受试者谁符合DSM-IV标准的BD，抑郁阶段，和55个对照组参加了这项研究。大多数患者被诊断为双相II型障碍。使用剑桥神经心理测试自动化Battery.Results的测试对情绪依赖性或“热”、情绪独立性或“冷”认知任务的表现进行了评估：两组在一般智力和人口统计学变量方面匹配良好。未服药的抑郁BD组在“热”认知处理测试中的缺陷是明显的，例如剑桥赌博任务和概率记忆学习任务。然而，除了在抑郁症BD受试者的空间跨度测试上的缺陷外，各组在大多数“冷”认知处理的测量上表现相当，例如视觉记忆，注意力和工作记忆。结论：这些数据表明，抑郁症BD受试者在涉及奖励处理，短期空间记忆储存和对负反馈敏感性的测试上的缺陷代表了疾病本身的影响，而不是情绪稳定药物。
Objectives:Neuropsychological studies in subjects with bipolar disorder (BD) have reported deficits on a variety of cognitive measures. However, because the majority of subjects were medicated at the time of testing in previous studies, it is currently unclear whether the pattern of deficits reported is related to BD itself or to psychotropic medication. We addressed this issue by examining cognitive performance in a group of unmedicated, currently depressed subjects with BD.Methods:Forty‐nine unmedicated subjects who met DSM‐IV criteria for BD, depressed phase, and 55 control subjects participated in this study. Most patients were diagnosed with bipolar II disorder. Performance on emotion‐dependent, or ‘hot’, and emotion‐independent, or ‘cold’, cognitive tasks was assessed using tests from the Cambridge Neuropsychological Test Automated Battery.Results:The groups were well matched with respect to general intelligence and demographic variables. Deficits in the unmedicated depressed BD group were apparent on tests tapping ‘hot’ cognitive processing, for example the Cambridge Gamble task and the Probabilistic Reversal Learning task. However, other than a deficit on the Spatial Span test in the depressed BD subjects, the groups performed equivalently on most measures of ‘cold’ cognitive processing, for example visual memory, attention, and working memory.Conclusions:These data suggest that deficits on tests involving reward processing, short‐term spatial memory storage, and sensitivity to negative feedback in depressed BD subjects represent an effect of the illness itself and not mood‐stabilizing medication.