Emerging significance of ER-coregulator PELP1/MNAR in cancer.
Emerging significance of ER-coregulator PELP1/MNAR in cancer.
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DOI：
10.14670/hh-22.91
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发表时间：
2007
影响因子：
2
通讯作者：
Sujit S. Nair;R. Vadlamudi
中科院分区：
文献类型：
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作者：
Sujit S. Nair;R. Vadlamudi
雌激素受体ER α和ER β与多种癌症的进展有关。雌激素受体的作用受雌激素受体辅调节蛋白的调节，包括富含脯氨酸、谷氨酸和亮氨酸的蛋白1（PELP 1/MNAR）。PELP 1已被证明参与ER的基因组和非基因组功能。PELP 1/MNAR的表达和定位在多种肿瘤中失调，并与癌细胞系中激素抗性的发展有关。新出现的数据表明，PELP 1/MNAR与许多蛋白质相互作用，并激活几个癌基因，包括Src激酶，磷脂酰肌醇3激酶（PI 3 K），信号转导和转录激活因子3（STAT 3）。这些新的结果表明，PELP 1/MNAR可能作为一个癌基因，以及与其他癌基因的合作。因此，PELP 1/MNAR可能有助于癌细胞的致瘤潜力，作为一个支架蛋白，耦合各种信号复合物与ER。
The estrogen receptors ERalpha and ERbeta have been implicated in the progression of a wide variety of cancers. The actions of ER are regulated by ER coregulator proteins, including proline-, glutamic acid- and leucine-rich-protein-1 (PELP1/MNAR). PELP1 has been shown to participate in both genomic and nongenomic functions of ER. The expression and localization of PELP1/MNAR are deregulated in a wide variety of tumors and have been implicated in the development of hormonal resistance in cancer cell lines. Emerging data suggest that PELP1/MNAR interacts with many proteins and activates several oncogenes, including Src kinase, phosphotidyl inositol 3 kinase (PI3K), and signal transducers and activators of transcription 3 (STAT3). These new results suggest that PELP1/MNAR may act as an oncogene as well as cooperating with other oncogenes. Thus, PELP1/MNAR may contribute to the tumorigenic potential of cancer cells by serving as a scaffolding protein that couples various signaling complexes with ER.